ACAD9 [The Human Chemical-Genetic Interaction Map Project]

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======= ACAD9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACAD9
  * **<color #00a2e8>Official Name</color>**: acyl-CoA dehydrogenase family member 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=28976|28976]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H845|Q9H845]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACAD9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACAD9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611103|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the acyl-CoA dehydrogenase family. Members of this family of proteins localize to the mitochondria and catalyze the rate-limiting step in the beta-oxidation of fatty acyl-CoA. The encoded protein is specifically active toward palmitoyl-CoA and long-chain unsaturated substrates. Mutations in this gene cause acyl-CoA dehydrogenase family member type 9 deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for mitochondrial complex I assembly (PubMed:20816094, PubMed:24158852). Has a dehydrogenase activity on palmitoyl-CoA (C16:0) and stearoyl-CoA (C18:0). It is three times more active on palmitoyl-CoA than on stearoyl-CoA. However, it does not play a primary role in long-chain fatty acid oxidation in vivo (PubMed:20816094, PubMed:24158852). Has little activity on octanoyl-CoA (C8:0), butyryl-CoA (C4:0) or isovaleryl-CoA (5:0). {ECO:0000269|PubMed:20816094, ECO:0000269|PubMed:24158852}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Acyl-CoA dh M|
|Acyl-CoA dh 2|
|Acyl-CoA dh N|
|Acyl-CoA dh 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|medium-chain-acyl-CoA dehydrogenase activity|
|very-long-chain-acyl-CoA dehydrogenase activity|
|long-chain-acyl-CoA dehydrogenase activity|
|medium-chain fatty acid metabolic process|
|fatty-acyl-CoA binding|
|flavin adenine dinucleotide binding|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|mitochondrial respiratory chain complex assembly|
|mitochondrial membrane|
|long-chain fatty acid metabolic process|
|fatty acid metabolic process|
|mitochondrial inner membrane|
|dendrite|
|mitochondrion organization|
|monocarboxylic acid metabolic process|
|cellular protein-containing complex assembly|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|mitochondrion|
|protein-containing complex assembly|
|small molecule metabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.72|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.72|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.77|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.78|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.78|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.81|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.82|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.87|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.91|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.95|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.01|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.06|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.07|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.11|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.11|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.16|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.17|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.29|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|2.3|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.4|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.41|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.53|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.86|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.35|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|4.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa1|NDUFA1]]|0.717|
|[[:human genes:n:ndufs2|NDUFS2]]|0.711|
|[[:human genes:n:ndufb9|NDUFB9]]|0.708|
|[[:human genes:n:nubpl|NUBPL]]|0.688|
|[[:human genes:n:ndufb11|NDUFB11]]|0.687|
|[[:human genes:g:grsf1|GRSF1]]|0.686|
|[[:human genes:m:mto1|MTO1]]|0.675|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.654|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.641|
|[[:human genes:n:ndufa11|NDUFA11]]|0.629|
|[[:human genes:n:ndufc2|NDUFC2]]|0.629|
|[[:human genes:n:ndufa2|NDUFA2]]|0.627|
|[[:human genes:n:ndufa3|NDUFA3]]|0.625|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.621|
|[[:human genes:n:ndufb7|NDUFB7]]|0.62|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.616|
|[[:human genes:n:ndufb10|NDUFB10]]|0.608|
|[[:human genes:n:ndufv1|NDUFV1]]|0.604|
|[[:human genes:f:fastkd2|FASTKD2]]|0.603|
|[[:human genes:n:ndufs5|NDUFS5]]|0.601|
|[[:human genes:n:ndufa8|NDUFA8]]|0.6|
|[[:human genes:n:ndufs8|NDUFS8]]|0.599|
|[[:human genes:c:chchd1|CHCHD1]]|0.597|
|[[:human genes:i:iba57|IBA57]]|0.595|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.585|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.583|
|[[:human genes:n:ndufb4|NDUFB4]]|0.582|
|[[:human genes:n:ndufc1|NDUFC1]]|0.58|
|[[:human genes:p:pet117|PET117]]|0.579|
|[[:human genes:m:mtif2|MTIF2]]|0.577|
|[[:human genes:p:pet112|PET112]]|0.575|
|[[:human genes:n:ndufa10|NDUFA10]]|0.568|
|[[:human genes:n:ndufv2|NDUFV2]]|0.566|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.566|
|[[:human genes:n:ndufb6|NDUFB6]]|0.564|
|[[:human genes:e:ecsit|ECSIT]]|0.564|
|[[:human genes:m:mettl17|METTL17]]|0.559|
|[[:human genes:m:mcat|MCAT]]|0.556|
|[[:human genes:t:tfb1m|TFB1M]]|0.554|
|[[:human genes:p:polrmt|POLRMT]]|0.554|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.552|
|[[:human genes:d:ddx28|DDX28]]|0.547|
|[[:human genes:n:ndufb5|NDUFB5]]|0.546|
|[[:human genes:n:ndufb2|NDUFB2]]|0.545|
|[[:human genes:m:mterfd1|MTERFD1]]|0.544|
|[[:human genes:c:coq7|COQ7]]|0.542|
|[[:human genes:q:qrsl1|QRSL1]]|0.539|
|[[:human genes:m:malsu1|MALSU1]]|0.536|
|[[:human genes:n:nars2|NARS2]]|0.536|
|[[:human genes:l:lars2|LARS2]]|0.536|
|[[:human genes:n:ndufs7|NDUFS7]]|0.536|
|[[:human genes:c:c1qbp|C1QBP]]|0.535|
|[[:human genes:m:mrps21|MRPS21]]|0.534|
|[[:human genes:p:polg2|POLG2]]|0.533|
|[[:human genes:f:ftsj2|FTSJ2]]|0.532|
|[[:human genes:e:eral1|ERAL1]]|0.531|
|[[:human genes:s:sfxn4|SFXN4]]|0.53|
|[[:human genes:s:ssbp1|SSBP1]]|0.528|
|[[:human genes:g:glrx5|GLRX5]]|0.527|
|[[:human genes:p:pde12|PDE12]]|0.526|
|[[:human genes:n:nsun4|NSUN4]]|0.523|
|[[:human genes:m:mrps27|MRPS27]]|0.523|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.522|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.522|
|[[:human genes:c:cars2|CARS2]]|0.522|
|[[:human genes:w:wars2|WARS2]]|0.521|
|[[:human genes:m:mtg1|MTG1]]|0.52|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.52|
|[[:human genes:n:ndufa13|NDUFA13]]|0.518|
|[[:human genes:p:prepl|PREPL]]|0.518|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.515|
|[[:human genes:t:tmem261|TMEM261]]|0.509|
|[[:human genes:a:atp5sl|ATP5SL]]|0.508|
|[[:human genes:c:coq2|COQ2]]|0.508|
|[[:human genes:n:ndufs3|NDUFS3]]|0.506|
|[[:human genes:m:mrpl21|MRPL21]]|0.505|
|[[:human genes:m:mrps25|MRPS25]]|0.505|
|[[:human genes:m:mrpl3|MRPL3]]|0.503|
|[[:human genes:m:mrpl45|MRPL45]]|0.502|
|[[:human genes:p:polg|POLG]]|0.502|
|[[:human genes:n:ndufs1|NDUFS1]]|0.501|
|[[:human genes:f:foxred1|FOXRED1]]|0.501|
|[[:human genes:m:mipep|MIPEP]]|0.5|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.499|
|[[:human genes:m:mrpl43|MRPL43]]|0.499|
|[[:human genes:s:slc25a51|SLC25A51]]|0.497|
|[[:human genes:r:rpusd3|RPUSD3]]|0.497|
|[[:human genes:d:dap3|DAP3]]|0.493|
|[[:human genes:c:c17orf89|C17orf89]]|0.492|
|[[:human genes:a:aars2|AARS2]]|0.492|
|[[:human genes:n:ndufa6|NDUFA6]]|0.489|
|[[:human genes:t:tsfm|TSFM]]|0.488|
|[[:human genes:m:mrps6|MRPS6]]|0.488|
|[[:human genes:c:clpp|CLPP]]|0.487|
|[[:human genes:n:ndufa9|NDUFA9]]|0.487|
|[[:human genes:p:ptcd3|PTCD3]]|0.482|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.481|
|[[:human genes:m:mrpl22|MRPL22]]|0.48|
|[[:human genes:c:c12orf65|C12orf65]]|0.48|
|[[:human genes:n:ndufb8|NDUFB8]]|0.476|
|[[:human genes:r:rbfa|RBFA]]|0.476|
|[[:human genes:p:pars2|PARS2]]|0.475|
|[[:human genes:g:gfm1|GFM1]]|0.473|
|[[:human genes:m:mrpl23|MRPL23]]|0.471|
|[[:human genes:y:yars2|YARS2]]|0.471|
|[[:human genes:m:mrps35|MRPS35]]|0.469|
|[[:human genes:t:trub2|TRUB2]]|0.468|
|[[:human genes:e:ears2|EARS2]]|0.465|
|[[:human genes:n:noa1|NOA1]]|0.464|
|[[:human genes:m:mrps12|MRPS12]]|0.463|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.462|
|[[:human genes:i:ict1|ICT1]]|0.462|
|[[:human genes:c:coa3|COA3]]|0.462|
|[[:human genes:m:mrpl53|MRPL53]]|0.462|
|[[:human genes:g:gfm2|GFM2]]|0.46|
|[[:human genes:r:rmnd1|RMND1]]|0.459|
|[[:human genes:m:mrpl44|MRPL44]]|0.458|
|[[:human genes:c:cluh|CLUH]]|0.458|
|[[:human genes:m:mrp63|MRP63]]|0.457|
|[[:human genes:m:mrpl13|MRPL13]]|0.455|
|[[:human genes:m:mrps22|MRPS22]]|0.451|
|[[:human genes:t:tomm20|TOMM20]]|0.449|
|[[:human genes:s:selrc1|SELRC1]]|0.448|
|[[:human genes:m:mrps5|MRPS5]]|0.446|
|[[:human genes:t:tefm|TEFM]]|0.445|
|[[:human genes:t:tars2|TARS2]]|0.444|
|[[:human genes:w:wbscr16|WBSCR16]]|0.444|
|[[:human genes:c:c10orf2|C10orf2]]|0.444|
|[[:human genes:m:mrps10|MRPS10]]|0.443|
|[[:human genes:m:mrps26|MRPS26]]|0.443|
|[[:human genes:m:mrps16|MRPS16]]|0.443|
|[[:human genes:m:mrps34|MRPS34]]|0.44|
|[[:human genes:m:mrpl17|MRPL17]]|0.44|
|[[:human genes:a:aifm1|AIFM1]]|0.439|
|[[:human genes:m:mrpl49|MRPL49]]|0.439|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.438|
|[[:human genes:n:nfu1|NFU1]]|0.438|
|[[:human genes:m:mrps18b|MRPS18B]]|0.436|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.435|
|[[:human genes:m:mrpl47|MRPL47]]|0.432|
|[[:human genes:m:mterfd2|MTERFD2]]|0.428|
|[[:human genes:n:ndufa5|NDUFA5]]|0.428|
|[[:human genes:r:rars2|RARS2]]|0.428|
|[[:human genes:m:mrpl1|MRPL1]]|0.428|
|[[:human genes:v:vars2|VARS2]]|0.425|
|[[:human genes:l:lrpprc|LRPPRC]]|0.424|
|[[:human genes:p:prim1|PRIM1]]|0.422|
|[[:human genes:m:mrpl12|MRPL12]]|0.421|
|[[:human genes:s:slc25a52|SLC25A52]]|0.419|
|[[:human genes:m:mrpl2|MRPL2]]|0.417|
|[[:human genes:m:mrps9|MRPS9]]|0.417|
|[[:human genes:m:mrpl15|MRPL15]]|0.416|
|[[:human genes:m:mtg2|MTG2]]|0.416|
|[[:human genes:f:fars2|FARS2]]|0.415|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.415|
|[[:human genes:m:mrpl28|MRPL28]]|0.414|
|[[:human genes:m:mrps28|MRPS28]]|0.414|
|[[:human genes:y:ybey|YBEY]]|0.413|
|[[:human genes:c:coa6|COA6]]|0.412|
|[[:human genes:f:fastkd5|FASTKD5]]|0.412|
|[[:human genes:m:mrpl38|MRPL38]]|0.411|
|[[:human genes:p:pnpt1|PNPT1]]|0.409|
|[[:human genes:d:dars2|DARS2]]|0.409|
|[[:human genes:m:mrpl24|MRPL24]]|0.408|
|[[:human genes:c:cox11|COX11]]|0.408|
|[[:human genes:m:mrps33|MRPS33]]|0.408|
|[[:human genes:s:slc25a3|SLC25A3]]|0.408|
|[[:human genes:s:sco2|SCO2]]|0.406|
|[[:human genes:r:rpusd4|RPUSD4]]|0.405|
|[[:human genes:t:tfam|TFAM]]|0.404|
|[[:human genes:h:hars2|HARS2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 570
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACAD9 Expression in NALM6 Cells: 5.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>