ACAN [The Human Chemical-Genetic Interaction Map Project]

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======= ACAN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACAN
  * **<color #00a2e8>Official Name</color>**: aggrecan
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=176|176]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16112|P16112]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACAN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACAN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/155760|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin C|
|Xlink|
|V-set|
|Sushi|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|perisynaptic extracellular matrix|
|keratan sulfate catabolic process|
|extracellular matrix structural constituent conferring compression resistance|
|cartilage condensation|
|cell aggregation|
|hyaluronic acid binding|
|keratan sulfate biosynthetic process|
|keratan sulfate metabolic process|
|chondrocyte development|
|collagen fibril organization|
|sulfur compound catabolic process|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|GABA-ergic synapse|
|proteoglycan biosynthetic process|
|chondrocyte differentiation|
|basement membrane|
|proteoglycan metabolic process|
|lysosomal lumen|
|Golgi lumen|
|glycosaminoglycan biosynthetic process|
|mucopolysaccharide metabolic process|
|aminoglycan biosynthetic process|
|extracellular matrix structural constituent|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|cartilage development|
|carbohydrate binding|
|sulfur compound biosynthetic process|
|carbohydrate derivative catabolic process|
|connective tissue development|
|extracellular matrix|
|skeletal system morphogenesis|
|glycoprotein biosynthetic process|
|extracellular matrix organization|
|glutamatergic synapse|
|collagen-containing extracellular matrix|
|sulfur compound metabolic process|
|extracellular structure organization|
|glycoprotein metabolic process|
|supramolecular fiber organization|
|skeletal system development|
|heart development|
|carbohydrate derivative biosynthetic process|
|circulatory system development|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|central nervous system development|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|organonitrogen compound biosynthetic process|
|cell development|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.91|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.74|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.8|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3217
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.22 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACAN Expression in NALM6 Cells: 1.22'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>