ACBD3 [The Human Chemical-Genetic Interaction Map Project]

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======= ACBD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACBD3
  * **<color #00a2e8>Official Name</color>**: acyl-CoA binding domain containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64746|64746]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H3P7|Q9H3P7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACBD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACBD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606809|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). {ECO:0000250|UniProtKB:Q8BMP6, ECO:0000269|PubMed:11590181, ECO:0000269|PubMed:27009356}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ACBP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fatty-acyl-CoA binding|
|protein kinase A regulatory subunit binding|
|steroid biosynthetic process|
|steroid metabolic process|
|lipid biosynthetic process|
|Golgi membrane|
|Golgi apparatus|
|lipid metabolic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-4.58|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-3.95|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-3.18|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.73|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.63|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.6|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.48|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.33|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.32|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-2.24|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.23|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.19|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-2.15|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.99|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.98|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.94|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.85|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.82|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.8|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.78|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.74|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.71|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.71|
|[[:results:exp519|RS-1 10μM R08 exp519]]|2.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tm9sf3|TM9SF3]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8756
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACBD3 Expression in NALM6 Cells: 5.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>