ACBD4 [The Human Chemical-Genetic Interaction Map Project]

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======= ACBD4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACBD4
  * **<color #00a2e8>Official Name</color>**: acyl-CoA binding domain containing 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79777|79777]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NC06|Q8NC06]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACBD4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACBD4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619968|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ACBP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fatty-acyl-CoA binding|
|lipid binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.96|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:exosc5|EXOSC5]]|0.462|
|[[:human genes:p:psma6|PSMA6]]|0.459|
|[[:human genes:t:terf1|TERF1]]|0.458|
|[[:human genes:d:disp2|DISP2]]|0.45|
|[[:human genes:p:psmb4|PSMB4]]|0.447|
|[[:human genes:p:ppm1d|PPM1D]]|0.438|
|[[:human genes:z:zfand5|ZFAND5]]|0.438|
|[[:human genes:p:psma7|PSMA7]]|0.435|
|[[:human genes:a:akt1s1|AKT1S1]]|0.433|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.433|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.432|
|[[:human genes:g:gramd1a|GRAMD1A]]|0.429|
|[[:human genes:a:akirin2|AKIRIN2]]|0.426|
|[[:human genes:t:tceb3c|TCEB3C]]|0.416|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.415|
|[[:human genes:x:xylt2|XYLT2]]|0.414|
|[[:human genes:r:rps12|RPS12]]|0.413|
|[[:human genes:p:pold1|POLD1]]|0.413|
|[[:human genes:t:twistnb|TWISTNB]]|0.411|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.41|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.41|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.407|
|[[:human genes:p:psmd11|PSMD11]]|0.407|
|[[:human genes:d:dhx38|DHX38]]|0.405|
|[[:human genes:l:lrr1|LRR1]]|0.404|
|[[:human genes:c:ccdc116|CCDC116]]|0.403|
|[[:human genes:c:cdc45|CDC45]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1955
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.22 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACBD4 Expression in NALM6 Cells: 2.22'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>