ACD [The Human Chemical-Genetic Interaction Map Project]

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======= ACD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACD
  * **<color #00a2e8>Official Name</color>**: ACD shelterin complex subunit and telomerase recruitment factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65057|65057]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96AP0|Q96AP0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609377|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis. {ECO:0000269|PubMed:15181449, ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378, ECO:0000269|PubMed:17237768, ECO:0000269|PubMed:20231318, ECO:0000269|PubMed:25205116, ECO:0000269|PubMed:25233904}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Telomere Pot1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of single-stranded telomeric DNA binding|
|positive regulation of single-stranded telomeric DNA binding|
|positive regulation of telomeric DNA binding|
|regulation of telomeric DNA binding|
|telomere assembly|
|shelterin complex|
|protection from non-homologous end joining at telomere|
|establishment of protein localization to telomere|
|nuclear telomere cap complex|
|telomere maintenance in response to DNA damage|
|establishment of protein localization to chromosome|
|protein localization to chromosome, telomeric region|
|telomere capping|
|DNA polymerase binding|
|negative regulation of telomere maintenance via telomerase|
|telomeric DNA binding|
|negative regulation of telomere maintenance via telomere lengthening|
|positive regulation of telomere maintenance via telomerase|
|positive regulation of telomerase activity|
|negative regulation of telomere maintenance|
|positive regulation of telomere maintenance via telomere lengthening|
|negative regulation of DNA biosynthetic process|
|positive regulation of telomere maintenance|
|regulation of telomerase activity|
|regulation of telomere maintenance via telomerase|
|positive regulation of DNA binding|
|regulation of telomere maintenance via telomere lengthening|
|protein localization to chromosome|
|positive regulation of DNA biosynthetic process|
|regulation of telomere maintenance|
|telomere maintenance|
|telomere organization|
|nuclear chromosome, telomeric region|
|regulation of DNA biosynthetic process|
|negative regulation of DNA metabolic process|
|regulation of DNA binding|
|negative regulation of chromosome organization|
|positive regulation of chromosome organization|
|positive regulation of binding|
|positive regulation of DNA metabolic process|
|protein-containing complex binding|
|nuclear body|
|anatomical structure homeostasis|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|regulation of binding|
|establishment of protein localization to organelle|
|positive regulation of organelle organization|
|positive regulation of transferase activity|
|negative regulation of cellular component organization|
|protein localization to organelle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|regulation of transferase activity|
|intracellular protein transport|
|chromosome organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|cellular response to stress|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.95|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.91|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.73|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:exosc5|EXOSC5]]|0.466|
|[[:human genes:n:nupl1|NUPL1]]|0.464|
|[[:human genes:a:akirin2|AKIRIN2]]|0.453|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.438|
|[[:human genes:c:cactin|CACTIN]]|0.43|
|[[:human genes:p:psmb2|PSMB2]]|0.423|
|[[:human genes:p:polr2j3|POLR2J3]]|0.422|
|[[:human genes:t:tspy8|TSPY8]]|0.409|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.409|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.407|
|[[:human genes:g:gosr2|GOSR2]]|0.406|
|[[:human genes:p:pole|POLE]]|0.405|
|[[:human genes:r:rps28|RPS28]]|0.403|
|[[:human genes:l:loc643669|LOC643669]]|0.402|
|[[:human genes:d:dock6|DOCK6]]|0.402|
|[[:human genes:c:copb1|COPB1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2051
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACD Expression in NALM6 Cells: 4.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>