ACHE [The Human Chemical-Genetic Interaction Map Project]

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======= ACHE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACHE
  * **<color #00a2e8>Official Name</color>**: acetylcholinesterase (Cartwright blood group)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=43|43]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22303|P22303]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACHE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACHE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/100740|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 3|
|COesterase|
|AChE tetra|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of synaptic transmission, cholinergic|
|neurotransmitter receptor biosynthetic process|
|acetylcholinesterase activity|
|acetylcholine catabolic process in synaptic cleft|
|acetylcholine catabolic process|
|neurotransmitter receptor metabolic process|
|cholinesterase activity|
|acetylcholine metabolic process|
|receptor biosynthetic process|
|acetate ester metabolic process|
|serine hydrolase activity|
|regulation of synaptic transmission, cholinergic|
|synaptic cleft|
|hormone catabolic process|
|acetylcholine binding|
|amyloid precursor protein metabolic process|
|osteoblast development|
|neurotransmitter catabolic process|
|laminin binding|
|regulation of receptor recycling|
|synaptic transmission, cholinergic|
|carboxylic ester hydrolase activity|
|phosphatidylcholine biosynthetic process|
|neurotransmitter biosynthetic process|
|protein self-association|
|negative regulation of synaptic transmission|
|receptor internalization|
|collagen binding|
|phosphatidylcholine metabolic process|
|neuromuscular junction|
|hydrolase activity|
|amyloid-beta binding|
|basement membrane|
|neurotransmitter metabolic process|
|synapse assembly|
|positive regulation of cold-induced thermogenesis|
|anchored component of membrane|
|receptor metabolic process|
|osteoblast differentiation|
|retina development in camera-type eye|
|regulation of cold-induced thermogenesis|
|drug catabolic process|
|protein tetramerization|
|ammonium ion metabolic process|
|hormone metabolic process|
|glycerophospholipid biosynthetic process|
|DNA replication|
|glycerolipid biosynthetic process|
|receptor-mediated endocytosis|
|phospholipid biosynthetic process|
|ossification|
|synapse|
|positive regulation of protein secretion|
|synapse organization|
|positive regulation of peptide secretion|
|muscle organ development|
|glycerophospholipid metabolic process|
|camera-type eye development|
|regulation of neurotransmitter levels|
|eye development|
|visual system development|
|sensory system development|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|positive regulation of secretion by cell|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|positive regulation of protein transport|
|positive regulation of secretion|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of establishment of protein localization|
|synaptic signaling|
|regulation of protein secretion|
|muscle structure development|
|regulation of peptide secretion|
|drug metabolic process|
|protein complex oligomerization|
|regulation of hormone levels|
|organophosphate biosynthetic process|
|sensory organ development|
|cell junction|
|cell population proliferation|
|endocytosis|
|response to wounding|
|lipid biosynthetic process|
|cell surface|
|import into cell|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|protein homodimerization activity|
|organophosphate metabolic process|
|cell adhesion|
|biological adhesion|
|cellular lipid metabolic process|
|Golgi apparatus|
|positive regulation of transport|
|regulation of protein localization|
|cell-cell signaling|
|lipid metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|extracellular space|
|cell development|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|regulation of transport|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3637
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACHE Expression in NALM6 Cells: -3.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>