ACPP [The Human Chemical-Genetic Interaction Map Project]

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======= ACPP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACP3
  * **<color #00a2e8>Official Name</color>**: acid phosphatase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55|55]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15309|P15309]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACPP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACPP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/171790|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|His Phos 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|thiamine phosphate phosphatase activity|
|lysophosphatidic acid phosphatase activity|
|positive regulation of adenosine receptor signaling pathway|
|thiamine metabolic process|
|regulation of adenosine receptor signaling pathway|
|thiamine-containing compound metabolic process|
|adenosine metabolic process|
|acid phosphatase activity|
|5-nucleotidase activity|
|purine nucleobase metabolic process|
|positive regulation of G protein-coupled receptor signaling pathway|
|vesicle membrane|
|regulation of sensory perception of pain|
|regulation of sensory perception|
|nucleobase metabolic process|
|phosphatase activity|
|azurophil granule membrane|
|purine ribonucleoside metabolic process|
|purine nucleoside metabolic process|
|filopodium|
|ribonucleoside metabolic process|
|water-soluble vitamin metabolic process|
|protein homotetramerization|
|pyrimidine-containing compound metabolic process|
|nucleoside metabolic process|
|vitamin metabolic process|
|glycosyl compound metabolic process|
|regulation of nervous system process|
|regulation of G protein-coupled receptor signaling pathway|
|protein tetramerization|
|lysosomal membrane|
|dephosphorylation|
|protein homooligomerization|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|drug metabolic process|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|nucleobase-containing small molecule metabolic process|
|myeloid leukocyte activation|
|regulation of system process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|protein homodimerization activity|
|organophosphate metabolic process|
|leukocyte activation|
|secretion by cell|
|carbohydrate derivative metabolic process|
|export from cell|
|identical protein binding|
|cell activation|
|immune effector process|
|secretion|
|protein-containing complex assembly|
|extracellular space|
|positive regulation of signal transduction|
|small molecule metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.85|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17801
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACPP Expression in NALM6 Cells: 0.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>