ACTG1 [The Human Chemical-Genetic Interaction Map Project]

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======= ACTG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACTG1
  * **<color #00a2e8>Official Name</color>**: actin gamma 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=71|71]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P63261|P63261]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACTG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACTG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102560|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Actin gamma 1, encoded by this gene, is a cytoplasmic actin found in all cell types. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss and also with Baraitser-Winter syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Actin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|structural constituent of postsynaptic actin cytoskeleton|
|dense body|
|profilin binding|
|postsynaptic actin cytoskeleton organization|
|postsynaptic cytoskeleton organization|
|calyx of Held|
|myofibril|
|filamentous actin|
|presynaptic endocytosis|
|synaptic vesicle endocytosis|
|platelet aggregation|
|sarcomere organization|
|synaptic vesicle recycling|
|homotypic cell-cell adhesion|
|phagocytic vesicle|
|myofibril assembly|
|retina homeostasis|
|actin filament|
|Schaffer collateral - CA1 synapse|
|ephrin receptor signaling pathway|
|postsynapse organization|
|structural constituent of cytoskeleton|
|cellular component assembly involved in morphogenesis|
|actomyosin structure organization|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|striated muscle cell development|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|platelet activation|
|Fc-gamma receptor signaling pathway|
|blood microparticle|
|muscle cell development|
|cellular response to interferon-gamma|
|cell junction assembly|
|response to interferon-gamma|
|tissue homeostasis|
|striated muscle cell differentiation|
|cell junction organization|
|Fc receptor signaling pathway|
|muscle cell differentiation|
|synapse organization|
|blood coagulation|
|ubiquitin protein ligase binding|
|coagulation|
|hemostasis|
|multicellular organismal homeostasis|
|phagocytosis|
|anatomical structure homeostasis|
|cytoskeleton|
|focal adhesion|
|immune response-activating cell surface receptor signaling pathway|
|supramolecular fiber organization|
|muscle structure development|
|wound healing|
|immune response-regulating cell surface receptor signaling pathway|
|actin cytoskeleton organization|
|regulation of body fluid levels|
|cell-cell adhesion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|endocytosis|
|immune response-activating signal transduction|
|actin filament-based process|
|response to wounding|
|immune response-regulating signaling pathway|
|activation of immune response|
|import into cell|
|enzyme linked receptor protein signaling pathway|
|organelle assembly|
|innate immune response|
|cellular component morphogenesis|
|membrane organization|
|positive regulation of immune response|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|cellular response to cytokine stimulus|
|identical protein binding|
|cell activation|
|immune effector process|
|response to cytokine|
|cytoskeleton organization|
|positive regulation of immune system process|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|ATP binding|
|extracellular space|
|homeostatic process|
|cell development|
|regulation of immune system process|
|establishment of localization in cell|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.543|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 13/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3002
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACTG1 Expression in NALM6 Cells: 10.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>