ACTR6 [The Human Chemical-Genetic Interaction Map Project]

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======= ACTR6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACTR6
  * **<color #00a2e8>Official Name</color>**: actin related protein 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64431|64431]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZN1|Q9GZN1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACTR6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACTR6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619729|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Actin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Swr1 complex|
|nucleosome binding|
|histone exchange|
|ATP-dependent chromatin remodeling|
|nucleosome organization|
|chromatin remodeling|
|protein-DNA complex subunit organization|
|cytoskeleton|
|chromatin organization|
|chromosome organization|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.81|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-1.8|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.79|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 448/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|13/28|
|bone|22/25|
|breast|15/33|
|central nervous system|35/56|
|cervix|3/4|
|colorectal|6/17|
|esophagus|6/13|
|fibroblast|1/1|
|gastric|9/15|
|kidney|14/21|
|liver|13/20|
|lung|45/75|
|lymphocyte|9/14|
|ovary|19/26|
|pancreas|11/24|
|peripheral nervous system|11/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|16/24|
|soft tissue|2/7|
|thyroid|2/2|
|upper aerodigestive|16/22|
|urinary tract|24/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1627
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACTR6 Expression in NALM6 Cells: 5.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>