ACVR2B [The Human Chemical-Genetic Interaction Map Project]

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======= ACVR2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACVR2B
  * **<color #00a2e8>Official Name</color>**: activin A receptor type 2B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=93|93]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13705|Q13705]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACVR2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACVR2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602730|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. {ECO:0000269|PubMed:8622651}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|Activin recp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activin receptor activity, type II|
|transforming growth factor beta receptor activity, type II|
|activin receptor complex|
|positive regulation of activin receptor signaling pathway|
|lymphatic endothelial cell differentiation|
|embryonic foregut morphogenesis|
|foregut morphogenesis|
|type I transforming growth factor beta receptor binding|
|lymphangiogenesis|
|activin binding|
|transforming growth factor beta-activated receptor activity|
|venous blood vessel development|
|lymph vessel morphogenesis|
|retina vasculature development in camera-type eye|
|lymph vessel development|
|regulation of activin receptor signaling pathway|
|activin receptor signaling pathway|
|gastrulation with mouth forming second|
|protein serine/threonine/tyrosine kinase activity|
|blood vessel remodeling|
|growth factor binding|
|positive regulation of bone mineralization|
|insulin secretion|
|positive regulation of biomineral tissue development|
|positive regulation of biomineralization|
|negative regulation of cold-induced thermogenesis|
|digestive tract morphogenesis|
|SMAD binding|
|positive regulation of osteoblast differentiation|
|peptide hormone secretion|
|pancreas development|
|hormone secretion|
|regulation of bone mineralization|
|hormone transport|
|endothelial cell differentiation|
|odontogenesis of dentin-containing tooth|
|positive regulation of ossification|
|artery development|
|post-embryonic development|
|BMP signaling pathway|
|roof of mouth development|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|endothelium development|
|organ growth|
|tissue remodeling|
|transforming growth factor beta receptor signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|regulation of osteoblast differentiation|
|determination of left/right symmetry|
|odontogenesis|
|determination of bilateral symmetry|
|specification of symmetry|
|mesoderm development|
|digestive tract development|
|response to glucose|
|retina development in camera-type eye|
|response to hexose|
|digestive system development|
|regulation of cold-induced thermogenesis|
|response to monosaccharide|
|cellular response to transforming growth factor beta stimulus|
|protein secretion|
|gastrulation|
|establishment of protein localization to extracellular region|
|response to transforming growth factor beta|
|protein localization to extracellular region|
|lung development|
|signal release|
|response to carbohydrate|
|respiratory tube development|
|peptide secretion|
|regulation of ossification|
|respiratory system development|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|receptor complex|
|anterior/posterior pattern specification|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|skeletal system morphogenesis|
|kidney development|
|renal system development|
|camera-type eye development|
|urogenital system development|
|activation of protein kinase activity|
|regionalization|
|eye development|
|visual system development|
|protein serine/threonine kinase activity|
|sensory system development|
|developmental growth|
|growth|
|pattern specification process|
|blood vessel development|
|skeletal system development|
|cellular response to growth factor stimulus|
|vasculature development|
|cardiovascular system development|
|heart development|
|response to growth factor|
|positive regulation of protein kinase activity|
|regulation of hormone levels|
|sensory organ development|
|embryonic morphogenesis|
|positive regulation of kinase activity|
|protein-containing complex|
|tube morphogenesis|
|positive regulation of transferase activity|
|epithelial cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of protein kinase activity|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|regulation of transferase activity|
|secretion by cell|
|positive regulation of protein phosphorylation|
|export from cell|
|positive regulation of phosphorylation|
|epithelium development|
|cell-cell signaling|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|phosphorylation|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|protein transport|
|negative regulation of cellular biosynthetic process|
|peptide transport|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|amide transport|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.81|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.89|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.569|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5236
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACVR2B Expression in NALM6 Cells: 4.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>