ADAM10 [The Human Chemical-Genetic Interaction Map Project]

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======= ADAM10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADAM10
  * **<color #00a2e8>Official Name</color>**: ADAM metallopeptidase domain 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=102|102]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14672|O14672]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADAM10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADAM10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602192|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146). {ECO:0000250|UniProtKB:O35598, ECO:0000269|PubMed:11477090, ECO:0000269|PubMed:11786905, ECO:0000269|PubMed:12475894, ECO:0000269|PubMed:16239146, ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:21288900, ECO:0000269|PubMed:26686862}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Reprolysin|
|Pep M12B propep|
|Disintegrin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|constitutive protein ectodomain proteolysis|
|metalloendopeptidase activity involved in amyloid precursor protein catabolic process|
|PMA-inducible membrane protein ectodomain proteolysis|
|amyloid-beta formation|
|Notch receptor processing, ligand-dependent|
|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|
|monocyte activation|
|tetraspanin-enriched microdomain|
|amyloid precursor protein catabolic process|
|Notch receptor processing|
|pore complex|
|positive regulation of T cell chemotaxis|
|regulation of receptor localization to synapse|
|Golgi-associated vesicle|
|perinuclear endoplasmic reticulum|
|regulation of T cell chemotaxis|
|amyloid precursor protein metabolic process|
|membrane protein intracellular domain proteolysis|
|amyloid-beta metabolic process|
|pore complex assembly|
|positive regulation of lymphocyte chemotaxis|
|membrane protein ectodomain proteolysis|
|regulation of lymphocyte chemotaxis|
|synaptic membrane|
|regulation of protein localization to synapse|
|positive regulation of T cell migration|
|positive regulation of lymphocyte migration|
|membrane protein proteolysis|
|regulation of dendritic spine morphogenesis|
|regulation of T cell migration|
|cochlea development|
|regulation of lymphocyte migration|
|metallopeptidase activity|
|extracellular matrix disassembly|
|regulation of dendritic spine development|
|tertiary granule membrane|
|endopeptidase activity|
|positive regulation of leukocyte chemotaxis|
|postsynapse organization|
|regulation of dendrite morphogenesis|
|specific granule membrane|
|integrin-mediated signaling pathway|
|response to antineoplastic agent|
|regulation of postsynapse organization|
|regulation of Notch signaling pathway|
|metalloendopeptidase activity|
|regulation of leukocyte chemotaxis|
|regulation of protein localization to cell periphery|
|synaptic vesicle|
|Notch signaling pathway|
|positive regulation of leukocyte migration|
|integrin binding|
|SH3 domain binding|
|positive regulation of chemotaxis|
|dendritic spine|
|regulation of dendrite development|
|protein processing|
|positive regulation of cell growth|
|trans-Golgi network|
|regulation of protein localization to membrane|
|inner ear development|
|regulation of leukocyte migration|
|postsynaptic membrane|
|regulation of chemotaxis|
|regulation of synapse organization|
|ear development|
|protein maturation|
|regulation of synapse structure or activity|
|postsynaptic density|
|positive regulation of growth|
|response to tumor necrosis factor|
|synapse organization|
|negative regulation of cell adhesion|
|endoplasmic reticulum lumen|
|regulation of cell morphogenesis involved in differentiation|
|regulation of vasculature development|
|signaling receptor binding|
|extracellular matrix organization|
|glutamatergic synapse|
|post-translational protein modification|
|neuronal cell body|
|in utero embryonic development|
|extracellular structure organization|
|cellular component disassembly|
|focal adhesion|
|regulation of cell growth|
|protein kinase binding|
|neutrophil degranulation|
|regulation of cell morphogenesis|
|neutrophil activation involved in immune response|
|regulation of neuron projection development|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of cell motility|
|peptide metabolic process|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|spermatogenesis|
|sensory organ development|
|positive regulation of locomotion|
|male gamete generation|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|cell surface|
|Golgi membrane|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of cell adhesion|
|gamete generation|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulated exocytosis|
|regulation of cell projection organization|
|leukocyte mediated immunity|
|cellular amide metabolic process|
|exocytosis|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of cell migration|
|protein homodimerization activity|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|protein phosphorylation|
|embryo development|
|regulation of locomotion|
|Golgi apparatus|
|multi-organism reproductive process|
|regulation of cellular component movement|
|secretion by cell|
|response to drug|
|regulation of protein localization|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|secretion|
|positive regulation of immune system process|
|proteolysis|
|phosphorylation|
|reproductive process|
|reproduction|
|generation of neurons|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|regulation of immune system process|
|regulation of cell death|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|immune response|
|vesicle-mediated transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|-2.29|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.88|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9622
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADAM10 Expression in NALM6 Cells: 8.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>