ADAM8 [The Human Chemical-Genetic Interaction Map Project]

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======= ADAM8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADAM8
  * **<color #00a2e8>Official Name</color>**: ADAM metallopeptidase domain 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=101|101]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78325|P78325]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADAM8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADAM8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602267|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Possible involvement in extravasation of leukocytes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ADAM CR|
|Reprolysin|
|Pep M12B propep|
|Disintegrin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alpha9-beta1 integrin-ADAM8 complex|
|regulation of fibronectin-dependent thymocyte migration|
|positive regulation of fibronectin-dependent thymocyte migration|
|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|
|alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|
|dense core granule membrane|
|positive regulation of thymocyte migration|
|regulation of tumor necrosis factor (ligand) superfamily member 11 production|
|positive regulation of eosinophil migration|
|phagolysosome|
|tertiary granule|
|regulation of thymocyte migration|
|regulation of eosinophil migration|
|positive regulation of thymocyte apoptotic process|
|positive regulation of neutrophil extravasation|
|regulation of neutrophil extravasation|
|positive regulation of T cell differentiation in thymus|
|regulation of thymocyte apoptotic process|
|specific granule|
|positive regulation of T cell apoptotic process|
|leukocyte migration involved in inflammatory response|
|positive regulation of membrane protein ectodomain proteolysis|
|positive regulation of cellular extravasation|
|positive regulation of lymphocyte apoptotic process|
|positive regulation of bone resorption|
|positive regulation of bone remodeling|
|regulation of membrane protein ectodomain proteolysis|
|positive regulation of protein processing|
|regulation of T cell differentiation in thymus|
|positive regulation of protein maturation|
|positive regulation of leukocyte apoptotic process|
|regulation of cellular extravasation|
|positive regulation of neutrophil migration|
|positive regulation of acute inflammatory response|
|podosome|
|positive regulation of T cell migration|
|positive regulation of tissue remodeling|
|regulation of T cell apoptotic process|
|regulation of neutrophil migration|
|positive regulation of lymphocyte migration|
|regulation of bone resorption|
|regulation of T cell migration|
|regulation of acute inflammatory response|
|lymphocyte chemotaxis|
|regulation of bone remodeling|
|regulation of lymphocyte apoptotic process|
|protein self-association|
|cell adhesion molecule binding|
|ficolin-1-rich granule membrane|
|regulation of lymphocyte migration|
|metallopeptidase activity|
|extracellular matrix disassembly|
|regulation of protein processing|
|lymphocyte migration|
|regulation of protein maturation|
|tertiary granule membrane|
|regulation of tissue remodeling|
|regulation of leukocyte apoptotic process|
|positive regulation of T cell differentiation|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|specific granule membrane|
|positive regulation of lymphocyte differentiation|
|metalloendopeptidase activity|
|positive regulation of leukocyte migration|
|regulation of T cell differentiation|
|positive regulation of inflammatory response|
|negative regulation of neuron apoptotic process|
|leukocyte chemotaxis|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|serine-type endopeptidase activity|
|positive regulation of protein kinase B signaling|
|regulation of lymphocyte differentiation|
|cellular response to hypoxia|
|positive regulation of hemopoiesis|
|regulation of leukocyte migration|
|cellular response to decreased oxygen levels|
|positive regulation of T cell activation|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|cell chemotaxis|
|cellular response to oxygen levels|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of protein catabolic process|
|regulation of protein kinase B signaling|
|positive regulation of cell-cell adhesion|
|positive regulation of MAP kinase activity|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of protein secretion|
|regulation of leukocyte differentiation|
|positive regulation of peptide secretion|
|regulation of leukocyte cell-cell adhesion|
|regulation of neuron death|
|angiogenesis|
|regulation of T cell activation|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|extracellular matrix organization|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|response to hypoxia|
|response to decreased oxygen levels|
|positive regulation of proteolysis|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|positive regulation of cellular catabolic process|
|leukocyte migration|
|response to oxygen levels|
|regulation of protein catabolic process|
|extracellular structure organization|
|regulation of cell-cell adhesion|
|cellular component disassembly|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|blood vessel morphogenesis|
|positive regulation of cell activation|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|positive regulation of secretion|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of defense response|
|blood vessel development|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of peptide secretion|
|neutrophil mediated immunity|
|inflammatory response|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|cell-cell adhesion|
|positive regulation of multi-organism process|
|vasculature development|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|cardiovascular system development|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of cell adhesion|
|regulation of cytokine production|
|positive regulation of cell death|
|regulated exocytosis|
|regulation of protein transport|
|calcium ion binding|
|cell morphogenesis|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|exocytosis|
|regulation of protein kinase activity|
|regulation of secretion|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|zinc ion binding|
|tube development|
|regulation of cell migration|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|cell migration|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of catabolic process|
|regulation of cellular component movement|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|proteolysis|
|locomotion|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5399
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADAM8 Expression in NALM6 Cells: 0.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>