ADAM9 [The Human Chemical-Genetic Interaction Map Project]

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======= ADAM9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADAM9
  * **<color #00a2e8>Official Name</color>**: ADAM metallopeptidase domain 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8754|8754]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13443|Q13443]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADAM9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADAM9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602713|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell- matrix interactions and regulate the motility of cells via interactions with integrins. {ECO:0000250|UniProtKB:Q61072}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pep M12B propep|
|Disintegrin|
|ADAM CR|
|Reprolysin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PMA-inducible membrane protein ectodomain proteolysis|
|intrinsic component of external side of plasma membrane|
|positive regulation of macrophage fusion|
|regulation of macrophage fusion|
|cell-cell adhesion mediated by integrin|
|monocyte activation|
|positive regulation of keratinocyte migration|
|regulation of keratinocyte migration|
|response to laminar fluid shear stress|
|positive regulation of membrane protein ectodomain proteolysis|
|response to manganese ion|
|positive regulation of cell adhesion mediated by integrin|
|regulation of membrane protein ectodomain proteolysis|
|cell adhesion mediated by integrin|
|membrane protein ectodomain proteolysis|
|laminin binding|
|positive regulation of syncytium formation by plasma membrane fusion|
|regulation of syncytium formation by plasma membrane fusion|
|response to fluid shear stress|
|membrane protein proteolysis|
|regulation of cell adhesion mediated by integrin|
|protein kinase C binding|
|activation of MAPKK activity|
|metallopeptidase activity|
|collagen binding|
|integrin-mediated signaling pathway|
|response to antineoplastic agent|
|transforming growth factor beta receptor signaling pathway|
|metalloendopeptidase activity|
|response to hydrogen peroxide|
|cell-matrix adhesion|
|integrin binding|
|SH3 domain binding|
|positive regulation of epithelial cell migration|
|response to glucocorticoid|
|response to calcium ion|
|cellular response to transforming growth factor beta stimulus|
|response to corticosteroid|
|response to transforming growth factor beta|
|cellular response to lipopolysaccharide|
|cell-substrate adhesion|
|cellular response to molecule of bacterial origin|
|response to reactive oxygen species|
|basolateral plasma membrane|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular response to biotic stimulus|
|positive regulation of protein catabolic process|
|regulation of epithelial cell migration|
|positive regulation of MAP kinase activity|
|response to tumor necrosis factor|
|positive regulation of protein secretion|
|keratinocyte differentiation|
|positive regulation of peptide secretion|
|response to antibiotic|
|response to lipopolysaccharide|
|epidermal cell differentiation|
|response to molecule of bacterial origin|
|response to steroid hormone|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|response to metal ion|
|skin development|
|regulation of protein catabolic process|
|response to oxidative stress|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|epidermis development|
|focal adhesion|
|positive regulation of protein transport|
|positive regulation of catabolic process|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|response to toxic substance|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|cell surface|
|positive regulation of transferase activity|
|regulation of cell adhesion|
|epithelial cell differentiation|
|response to bacterium|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of cellular catabolic process|
|regulation of cell migration|
|response to lipid|
|regulation of kinase activity|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|cell migration|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of catabolic process|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|response to cytokine|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.73|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.78|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.78|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.81|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.81|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10541
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADAM9 Expression in NALM6 Cells: 6.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>