ADARB1 [The Human Chemical-Genetic Interaction Map Project]

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======= ADARB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADARB1
  * **<color #00a2e8>Official Name</color>**: adenosine deaminase RNA specific B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=104|104]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78563|P78563]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADARB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADARB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601218|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|A deamin|
|dsrm|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hypoglossal nerve morphogenesis|
|hypoglossal nerve development|
|motor neuron apoptotic process|
|spinal cord ventral commissure morphogenesis|
|tRNA-specific adenosine deaminase activity|
|double-stranded RNA adenosine deaminase activity|
|motor behavior|
|negative regulation of protein kinase activity by regulation of protein phosphorylation|
|adenosine to inosine editing|
|facial nerve development|
|facial nerve morphogenesis|
|neuromuscular process controlling posture|
|preganglionic parasympathetic fiber development|
|parasympathetic nervous system development|
|base conversion or substitution editing|
|central nervous system projection neuron axonogenesis|
|innervation|
|cranial nerve morphogenesis|
|neuromuscular synaptic transmission|
|central nervous system neuron axonogenesis|
|positive regulation of viral genome replication|
|neuron apoptotic process|
|autonomic nervous system development|
|cranial nerve development|
|neuron death|
|positive regulation of viral life cycle|
|double-stranded RNA binding|
|nerve development|
|muscle tissue morphogenesis|
|central nervous system neuron development|
|multicellular organism growth|
|muscle organ morphogenesis|
|regulation of viral genome replication|
|spinal cord development|
|positive regulation of viral process|
|neuromuscular process|
|regulation of viral life cycle|
|mRNA binding|
|RNA modification|
|central nervous system neuron differentiation|
|defense response to virus|
|regulation of viral process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|response to virus|
|muscle organ development|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|axonogenesis|
|developmental growth|
|growth|
|negative regulation of protein phosphorylation|
|axon development|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell morphogenesis involved in neuron differentiation|
|trans-synaptic signaling|
|negative regulation of phosphorylation|
|synaptic signaling|
|muscle structure development|
|mRNA processing|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|positive regulation of multi-organism process|
|cell part morphogenesis|
|cell morphogenesis involved in differentiation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|behavior|
|negative regulation of protein modification process|
|neuron projection development|
|negative regulation of cell population proliferation|
|mRNA metabolic process|
|cell morphogenesis|
|innate immune response|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|neuron development|
|cellular component morphogenesis|
|regulation of cell migration|
|nucleolus|
|regulation of kinase activity|
|RNA processing|
|regulation of cell motility|
|apoptotic process|
|defense response to other organism|
|animal organ morphogenesis|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|immune effector process|
|cell death|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|regulation of cell cycle|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|nervous system process|
|RNA binding|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|RNA metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|immune response|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.91|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.82|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.77|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.72|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|1.79|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18282
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADARB1 Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>