ADH6 [The Human Chemical-Genetic Interaction Map Project]

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======= ADH6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADH6
  * **<color #00a2e8>Official Name</color>**: alcohol dehydrogenase 6 (class V)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=130|130]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P28332|P28332]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADH6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADH6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/103735|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ADH zinc N|
|ADH N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alcohol dehydrogenase (NAD) activity|
|alcohol dehydrogenase activity, zinc-dependent|
|ethanol oxidation|
|ethanol metabolic process|
|retinol dehydrogenase activity|
|retinoic acid metabolic process|
|retinol metabolic process|
|primary alcohol metabolic process|
|retinoid metabolic process|
|antibiotic metabolic process|
|diterpenoid metabolic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|response to ethanol|
|isoprenoid metabolic process|
|hormone metabolic process|
|response to alcohol|
|response to antibiotic|
|alcohol metabolic process|
|generation of precursor metabolites and energy|
|organic hydroxy compound metabolic process|
|drug metabolic process|
|response to toxic substance|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|zinc ion binding|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|lipid metabolic process|
|response to oxygen-containing compound|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp115|A-366 10μM R03 exp115]]|-2.27|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.01|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.92|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.79|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.77|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.72|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.71|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.71|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.79|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.83|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18861
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADH6 Expression in NALM6 Cells: -1.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>