ADPRM [The Human Chemical-Genetic Interaction Map Project]

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======= ADPRM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADPRM
  * **<color #00a2e8>Official Name</color>**: ADP-ribose/CDP-alcohol diphosphatase, manganese dependent
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56985|56985]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q3LIE5|Q3LIE5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADPRM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADPRM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621211|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP- choline and CDP-ethanolamine, but not other non-reducing ADP- sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Metallophos|
|Metallophos 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CDP-glycerol diphosphatase activity|
|ADP-ribose diphosphatase activity|
|nucleobase-containing small molecule catabolic process|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|nucleobase-containing small molecule metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.9|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.75|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.82|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.9|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16613
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADPRM Expression in NALM6 Cells: 2.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>