AFTPH [The Human Chemical-Genetic Interaction Map Project]

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======= AFTPH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AFTPH
  * **<color #00a2e8>Official Name</color>**: aftiphilin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54812|54812]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ULP2|Q6ULP2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AFTPH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AFTPH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619628|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in membrane trafficking.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|AP-1 adaptor complex|
|clathrin binding|
|trans-Golgi network membrane|
|intracellular membrane-bounded organelle|
|Golgi apparatus|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.91|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.86|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-1.73|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.75|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.76|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.77|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.84|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.87|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.9|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.04|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.12|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.61|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:ap1b1|AP1B1]]|0.511|
|[[:human genes:h:heatr5b|HEATR5B]]|0.456|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12343
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AFTPH Expression in NALM6 Cells: 5.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>