AGER [The Human Chemical-Genetic Interaction Map Project]

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======= AGER =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AGER
  * **<color #00a2e8>Official Name</color>**: advanced glycosylation end-product specific receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=177|177]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15109|Q15109]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AGER&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AGER|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600214|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ig|
|I-set|
|C2-set 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|advanced glycation end-product receptor activity|
|regulation of endothelin secretion|
|regulation of connective tissue replacement involved in inflammatory response wound healing|
|negative regulation of connective tissue replacement involved in inflammatory response wound healing|
|positive regulation of endothelin secretion|
|negative regulation of connective tissue replacement|
|sugar mediated signaling pathway|
|negative regulation of inflammatory response to wounding|
|glucose mediated signaling pathway|
|hexose mediated signaling|
|negative regulation of long-term synaptic depression|
|positive regulation of monocyte extravasation|
|regulation of inflammatory response to wounding|
|regulation of monocyte extravasation|
|regulation of connective tissue replacement|
|carbohydrate mediated signaling|
|regulation of spontaneous synaptic transmission|
|positive regulation of dendritic cell differentiation|
|positive regulation of interleukin-1 biosynthetic process|
|regulation of interleukin-1 biosynthetic process|
|positive regulation of interleukin-1 beta biosynthetic process|
|regulation of interleukin-1 beta biosynthetic process|
|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|
|positive regulation of aspartic-type peptidase activity|
|modulation of age-related behavioral decline|
|regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|
|positive regulation of monocyte chemotactic protein-1 production|
|regulation of aspartic-type peptidase activity|
|positive regulation of chemokine biosynthetic process|
|negative regulation of long-term synaptic potentiation|
|regulation of dendritic cell differentiation|
|regulation of long-term synaptic depression|
|induction of positive chemotaxis|
|regulation of chemokine biosynthetic process|
|S100 protein binding|
|positive regulation of interleukin-6 biosynthetic process|
|positive regulation of heterotypic cell-cell adhesion|
|regulation of monocyte chemotactic protein-1 production|
|positive regulation of cellular extravasation|
|transcytosis|
|negative regulation of interleukin-10 production|
|positive regulation of amyloid precursor protein catabolic process|
|astrocyte activation|
|positive regulation of tumor necrosis factor biosynthetic process|
|negative regulation of tissue remodeling|
|positive regulation of activated T cell proliferation|
|regulation of interleukin-6 biosynthetic process|
|positive regulation of mononuclear cell migration|
|positive regulation of positive chemotaxis|
|regulation of heterotypic cell-cell adhesion|
|regulation of positive chemotaxis|
|positive regulation of p38MAPK cascade|
|regulation of cellular extravasation|
|microglial cell activation|
|regulation of tumor necrosis factor biosynthetic process|
|leukocyte activation involved in inflammatory response|
|regulation of T cell mediated cytotoxicity|
|regulation of amyloid precursor protein catabolic process|
|negative regulation of blood circulation|
|positive regulation of interleukin-12 production|
|regulation of activated T cell proliferation|
|astrocyte development|
|glial cell activation|
|cellular response to amyloid-beta|
|neuroinflammatory response|
|regulation of p38MAPK cascade|
|regulation of long-term synaptic potentiation|
|regulation of mononuclear cell migration|
|response to amyloid-beta|
|scavenger receptor activity|
|macrophage activation|
|positive regulation of interleukin-1 beta production|
|regulation of interleukin-10 production|
|astrocyte differentiation|
|regulation of interleukin-12 production|
|positive regulation of chemokine production|
|positive regulation of interleukin-1 production|
|regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of cytokine biosynthetic process|
|cellular response to glucose stimulus|
|regulation of T cell mediated immunity|
|negative regulation of wound healing|
|cellular response to hexose stimulus|
|positive regulation of JUN kinase activity|
|cellular response to monosaccharide stimulus|
|regulation of tissue remodeling|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of leukocyte mediated cytotoxicity|
|regulation of chemokine production|
|cellular response to carbohydrate stimulus|
|amyloid-beta binding|
|regulation of interleukin-1 beta production|
|postsynapse|
|negative regulation of response to wounding|
|positive regulation of tumor necrosis factor production|
|regulation of JUN kinase activity|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|cellular glucose homeostasis|
|regulation of alpha-beta T cell activation|
|positive regulation of interleukin-6 production|
|positive regulation of T cell proliferation|
|regulation of interleukin-1 production|
|regulation of cell killing|
|regulation of cytokine biosynthetic process|
|glial cell development|
|regulation of NIK/NF-kappaB signaling|
|regulation of DNA binding|
|positive regulation of leukocyte migration|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|fibrillar center|
|positive regulation of chemotaxis|
|transmembrane signaling receptor activity|
|positive regulation of leukocyte proliferation|
|negative regulation of inflammatory response|
|response to glucose|
|regulation of wound healing|
|positive regulation of JNK cascade|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|response to hexose|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor production|
|response to monosaccharide|
|regulation of lymphocyte mediated immunity|
|positive regulation of synaptic transmission|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|positive regulation of stress-activated MAPK cascade|
|regulation of response to wounding|
|positive regulation of stress-activated protein kinase signaling cascade|
|glial cell differentiation|
|response to carbohydrate|
|positive regulation of endopeptidase activity|
|glucose homeostasis|
|regulation of JNK cascade|
|carbohydrate homeostasis|
|positive regulation of hemopoiesis|
|regulation of synaptic plasticity|
|positive regulation of peptidase activity|
|regulation of leukocyte migration|
|positive regulation of T cell activation|
|regulation of cytokine secretion|
|signaling receptor activity|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|gliogenesis|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|positive regulation of cell-cell adhesion|
|learning or memory|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of MAP kinase activity|
|protein-containing complex binding|
|positive regulation of protein secretion|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|aging|
|regulation of blood circulation|
|positive regulation of peptide secretion|
|regulation of ERK1 and ERK2 cascade|
|regulation of leukocyte cell-cell adhesion|
|cognition|
|regulation of T cell activation|
|apical plasma membrane|
|cellular response to peptide|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|response to hypoxia|
|positive regulation of proteolysis|
|response to decreased oxygen levels|
|positive regulation of lymphocyte activation|
|negative regulation of response to external stimulus|
|regulation of binding|
|response to oxygen levels|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|response to peptide|
|protein localization to membrane|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of cell migration|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|cell junction|
|positive regulation of locomotion|
|endocytosis|
|response to wounding|
|behavior|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|regulation of system process|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|cell surface|
|regulation of cell activation|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|neuron projection development|
|import into cell|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|regulation of cell migration|
|regulation of kinase activity|
|cellular homeostasis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|leukocyte activation|
|defense response to other organism|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|response to organonitrogen compound|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|cell activation|
|response to nitrogen compound|
|regulation of response to external stimulus|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|cell projection organization|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|generation of neurons|
|response to oxygen-containing compound|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17123
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AGER Expression in NALM6 Cells: 3.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>