AGGF1 [The Human Chemical-Genetic Interaction Map Project]

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======= AGGF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AGGF1
  * **<color #00a2e8>Official Name</color>**: angiogenic factor with G-patch and FHA domains 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55109|55109]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N302|Q8N302]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AGGF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AGGF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608464|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.[provided by RefSeq, Sep 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G-patch 2|
|FHA|
|G-patch|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vasculogenesis|
|positive regulation of endothelial cell proliferation|
|regulation of endothelial cell proliferation|
|positive regulation of angiogenesis|
|positive regulation of vasculature development|
|positive regulation of epithelial cell proliferation|
|nucleic acid binding|
|regulation of angiogenesis|
|angiogenesis|
|regulation of vasculature development|
|regulation of epithelial cell proliferation|
|blood vessel morphogenesis|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|tube morphogenesis|
|perinuclear region of cytoplasm|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|cell adhesion|
|biological adhesion|
|regulation of anatomical structure morphogenesis|
|positive regulation of developmental process|
|regulation of cell population proliferation|
|positive regulation of multicellular organismal process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.33|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-2.2|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.13|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.78|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.7|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.74|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.75|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.76|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.92|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.05|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19069
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AGGF1 Expression in NALM6 Cells: 5.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>