AGO4 [The Human Chemical-Genetic Interaction Map Project]

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======= AGO4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AGO4
  * **<color #00a2e8>Official Name</color>**: argonaute RISC component 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=192670|192670]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HCK5|Q9HCK5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AGO4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AGO4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607356|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). {ECO:0000255|HAMAP- Rule:MF_03033, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:18552826, ECO:0000269|PubMed:18771919}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAZ|
|DUF1785|
|Piwi|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA cleavage involved in gene silencing by siRNA|
|mRNA cleavage involved in gene silencing|
|mRNA cleavage involved in gene silencing by miRNA|
|miRNA loading onto RISC involved in gene silencing by miRNA|
|RNA secondary structure unwinding|
|small RNA loading onto RISC|
|RISC-loading complex|
|regulation of translation, ncRNA-mediated|
|miRNA mediated inhibition of translation|
|negative regulation of translation, ncRNA-mediated|
|pre-miRNA processing|
|RISC complex|
|RNA interference|
|synaptonemal complex assembly|
|miRNA metabolic process|
|synaptonemal complex organization|
|mRNA cleavage|
|production of miRNAs involved in gene silencing by miRNA|
|miRNA binding|
|dsRNA processing|
|production of small RNA involved in gene silencing by RNA|
|Wnt signaling pathway, calcium modulating pathway|
|synapsis|
|single-stranded RNA binding|
|gene silencing by miRNA|
|male meiotic nuclear division|
|regulation of megakaryocyte differentiation|
|posttranscriptional gene silencing by RNA|
|homologous chromosome segregation|
|posttranscriptional gene silencing|
|chromosome organization involved in meiotic cell cycle|
|double-stranded RNA binding|
|P-body|
|gene silencing by RNA|
|meiotic chromosome segregation|
|meiosis I|
|meiosis I cell cycle process|
|negative regulation of translation|
|male gonad development|
|non-canonical Wnt signaling pathway|
|development of primary male sexual characteristics|
|negative regulation of cellular amide metabolic process|
|meiotic nuclear division|
|gene silencing|
|male sex differentiation|
|RNA phosphodiester bond hydrolysis|
|meiotic cell cycle process|
|gonad development|
|mRNA catabolic process|
|development of primary sexual characteristics|
|nuclear chromosome segregation|
|meiotic cell cycle|
|regulation of myeloid cell differentiation|
|ribonucleoprotein complex assembly|
|regulation of gene expression, epigenetic|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|sex differentiation|
|chromosome segregation|
|nuclear body|
|nuclear division|
|nucleic acid phosphodiester bond hydrolysis|
|organelle fission|
|regulation of translation|
|cellular process involved in reproduction in multicellular organism|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|nucleobase-containing compound catabolic process|
|ncRNA processing|
|regulation of cellular amide metabolic process|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|regulation of hemopoiesis|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|regulation of cell morphogenesis|
|posttranscriptional regulation of gene expression|
|male gamete generation|
|developmental process involved in reproduction|
|gamete generation|
|mRNA metabolic process|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|RNA processing|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cellular macromolecule catabolic process|
|multi-organism reproductive process|
|negative regulation of cell death|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|positive regulation of gene expression|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11612
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AGO4 Expression in NALM6 Cells: 4.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>