AGTPBP1 [The Human Chemical-Genetic Interaction Map Project]

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======= AGTPBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AGTPBP1
  * **<color #00a2e8>Official Name</color>**: ATP/GTP binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23287|23287]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPW5|Q9UPW5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AGTPBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AGTPBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606830|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|C-terminal protein deglutamylation|
|protein side chain deglutamylation|
|protein deglutamylation|
|cerebellar Purkinje cell differentiation|
|cerebellar Purkinje cell layer formation|
|cerebellar Purkinje cell layer morphogenesis|
|C-terminal protein amino acid modification|
|cell differentiation in hindbrain|
|cerebellar cortex formation|
|cerebellar Purkinje cell layer development|
|metallocarboxypeptidase activity|
|peptidyl-glutamic acid modification|
|cerebellar cortex morphogenesis|
|olfactory bulb development|
|olfactory lobe development|
|cerebellum morphogenesis|
|hindbrain morphogenesis|
|eye photoreceptor cell differentiation|
|cerebellar cortex development|
|tubulin binding|
|photoreceptor cell differentiation|
|cerebellum development|
|neuromuscular process|
|metencephalon development|
|eye morphogenesis|
|hindbrain development|
|central nervous system neuron differentiation|
|sensory organ morphogenesis|
|telencephalon development|
|eye development|
|visual system development|
|post-translational protein modification|
|sensory system development|
|forebrain development|
|mitochondrion organization|
|sensory organ development|
|intracellular membrane-bounded organelle|
|brain development|
|head development|
|zinc ion binding|
|nucleolus|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|central nervous system development|
|neuron differentiation|
|mitochondrion|
|proteolysis|
|nervous system process|
|generation of neurons|
|neurogenesis|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.18|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16178
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AGTPBP1 Expression in NALM6 Cells: 5.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>