AHCYL1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= AHCYL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AHCYL1
  * **<color #00a2e8>Official Name</color>**: adenosylhomocysteinase like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10768|10768]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43865|O43865]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AHCYL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AHCYL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607826|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5- trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5- trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L- homocysteine hydrolase activity (By similarity). {ECO:0000250|UniProtKB:B5DFN2, ECO:0000250|UniProtKB:Q80SW1, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:16793548, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:19224921, ECO:0000269|PubMed:20584908, ECO:0000269|PubMed:25237103}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|2-Hacid dh C|
|AdoHcyase NAD|
|AdoHcyase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adenosylhomocysteinase activity|
|S-adenosylmethionine cycle|
|epithelial fluid transport|
|angiotensin-activated signaling pathway|
|S-adenosylmethionine metabolic process|
|transepithelial transport|
|cellular response to angiotensin|
|response to angiotensin|
|one-carbon metabolic process|
|fluid transport|
|regulation of mRNA 3-end processing|
|mRNA polyadenylation|
|RNA polyadenylation|
|positive regulation of sodium ion transport|
|regulation of cardiac conduction|
|mRNA 3-end processing|
|regulation of sodium ion transport|
|regulation of anion transport|
|RNA 3-end processing|
|regulation of mRNA processing|
|protein export from nucleus|
|response to calcium ion|
|nuclear export|
|cellular modified amino acid metabolic process|
|regulation of heart contraction|
|coenzyme metabolic process|
|regulation of ion transmembrane transporter activity|
|nucleocytoplasmic transport|
|regulation of transmembrane transporter activity|
|nuclear transport|
|cellular response to peptide hormone stimulus|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of blood circulation|
|apical plasma membrane|
|cellular response to peptide|
|regulation of mRNA metabolic process|
|sulfur compound metabolic process|
|response to metal ion|
|regulation of metal ion transport|
|response to peptide hormone|
|cofactor metabolic process|
|response to peptide|
|mRNA processing|
|regulation of ion transmembrane transport|
|drug metabolic process|
|response to inorganic substance|
|regulation of transmembrane transport|
|regulation of system process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|mRNA metabolic process|
|regulation of ion transport|
|RNA processing|
|response to hormone|
|endoplasmic reticulum membrane|
|positive regulation of transport|
|intracellular protein transport|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|RNA binding|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|small molecule metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-2.77|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.75|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-2.73|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.29|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.21|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.13|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-2.05|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.99|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.98|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.92|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.9|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.89|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.89|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.88|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.85|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.83|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.79|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-1.75|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.7|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.74|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.76|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.79|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.8|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.81|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.84|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.89|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.91|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.91|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.95|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.04|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.17|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.19|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|2.2|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.26|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.28|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.31|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.34|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.4|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.47|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.58|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.59|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.66|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.8|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.84|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|3.13|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|3.2|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.33|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|3.4|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|3.44|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|3.48|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|3.57|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|3.68|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|3.73|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|4.01|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|4.57|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|4.6|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|4.62|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|4.86|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|5.01|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|5.07|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|5.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mapkapk5|MAPKAPK5]]|0.723|
|[[:human genes:s:slc4a7|SLC4A7]]|0.675|
|[[:human genes:m:mapk6|MAPK6]]|0.593|
|[[:human genes:a:atp1a1|ATP1A1]]|0.459|
|[[:human genes:p:pfkp|PFKP]]|0.454|
|[[:human genes:t:tmem161b|TMEM161B]]|0.451|
|[[:human genes:g:gpi|GPI]]|0.424|
|[[:human genes:b:brpf1|BRPF1]]|0.418|
|[[:human genes:h:hk2|HK2]]|0.415|
|[[:human genes:p:pigf|PIGF]]|0.414|
|[[:human genes:v:vps35|VPS35]]|0.408|
|[[:human genes:z:znf592|ZNF592]]|0.401|
|[[:human genes:v:vps29|VPS29]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 59/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|5/28|
|bone|0/26|
|breast|2/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|6/21|
|liver|5/20|
|lung|4/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|3/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 983
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AHCYL1 Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>