AK5 [The Human Chemical-Genetic Interaction Map Project]

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======= AK5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AK5
  * **<color #00a2e8>Official Name</color>**: adenylate kinase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26289|26289]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6K8|Q9Y6K8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AK5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AK5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608009|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269|PubMed:19647735, ECO:0000269|PubMed:23416111}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dpy-30|
|ADK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dADP biosynthetic process|
|purine deoxyribonucleoside diphosphate biosynthetic process|
|dADP metabolic process|
|purine deoxyribonucleotide biosynthetic process|
|purine deoxyribonucleoside diphosphate metabolic process|
|deoxyribonucleoside diphosphate biosynthetic process|
|ADP biosynthetic process|
|deoxyribonucleoside diphosphate metabolic process|
|purine nucleoside diphosphate biosynthetic process|
|purine ribonucleoside diphosphate biosynthetic process|
|ribonucleoside diphosphate biosynthetic process|
|adenylate kinase activity|
|nucleoside diphosphate biosynthetic process|
|purine deoxyribonucleotide metabolic process|
|2-deoxyribonucleotide biosynthetic process|
|deoxyribose phosphate biosynthetic process|
|nucleoside monophosphate phosphorylation|
|deoxyribonucleotide biosynthetic process|
|nucleoside diphosphate kinase activity|
|pyrimidine ribonucleotide biosynthetic process|
|pyrimidine ribonucleotide metabolic process|
|nucleobase-containing small molecule interconversion|
|2-deoxyribonucleotide metabolic process|
|deoxyribose phosphate metabolic process|
|deoxyribonucleotide metabolic process|
|pyrimidine nucleotide biosynthetic process|
|ADP metabolic process|
|pyrimidine-containing compound biosynthetic process|
|nucleoside diphosphate phosphorylation|
|pyrimidine nucleotide metabolic process|
|nucleotide phosphorylation|
|purine ribonucleoside diphosphate metabolic process|
|purine nucleoside diphosphate metabolic process|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside diphosphate metabolic process|
|nucleoside monophosphate metabolic process|
|nucleoside diphosphate metabolic process|
|nucleoside triphosphate metabolic process|
|pyrimidine-containing compound metabolic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|microtubule organizing center|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|ATP metabolic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp16|DABN 2μM R00 exp16]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.521|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7246
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.94 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AK5 Expression in NALM6 Cells: 1.94'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>