AKIRIN1 [The Human Chemical-Genetic Interaction Map Project]

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======= AKIRIN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AKIRIN1
  * **<color #00a2e8>Official Name</color>**: akirin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79647|79647]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H9L7|Q9H9L7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AKIRIN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AKIRIN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615164|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myoblast migration involved in skeletal muscle regeneration|
|negative regulation of skeletal muscle satellite cell proliferation|
|negative regulation of skeletal muscle cell proliferation|
|negative regulation of satellite cell differentiation|
|negative regulation of skeletal muscle cell differentiation|
|negative regulation of skeletal muscle tissue development|
|regulation of skeletal muscle satellite cell proliferation|
|myoblast migration|
|regulation of skeletal muscle cell proliferation|
|positive regulation of macrophage chemotaxis|
|regulation of skeletal muscle cell differentiation|
|positive regulation of macrophage migration|
|positive regulation of lamellipodium assembly|
|positive regulation of myoblast differentiation|
|muscle cell migration|
|regulation of macrophage chemotaxis|
|positive regulation of lamellipodium organization|
|regulation of lamellipodium assembly|
|skeletal muscle tissue regeneration|
|regulation of macrophage migration|
|regulation of lamellipodium organization|
|regulation of granulocyte chemotaxis|
|regulation of mononuclear cell migration|
|negative regulation of striated muscle tissue development|
|regulation of skeletal muscle tissue development|
|negative regulation of muscle organ development|
|negative regulation of muscle tissue development|
|regulation of myoblast differentiation|
|tissue regeneration|
|positive regulation of leukocyte chemotaxis|
|positive regulation of plasma membrane bounded cell projection assembly|
|regulation of leukocyte chemotaxis|
|positive regulation of leukocyte migration|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|positive regulation of chemotaxis|
|regeneration|
|regulation of leukocyte migration|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of chemotaxis|
|nuclear membrane|
|positive regulation of cell projection organization|
|developmental growth|
|growth|
|wound healing|
|positive regulation of cell migration|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|response to wounding|
|positive regulation of response to external stimulus|
|negative regulation of cell population proliferation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of cell migration|
|regulation of cell motility|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|locomotion|
|positive regulation of developmental process|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|regulation of immune system process|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.92|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.78|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.77|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.73|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.74|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.94|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pou2af1|POU2AF1]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9524
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AKIRIN1 Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>