AKR1C1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= AKR1C1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AKR1C1
  * **<color #00a2e8>Official Name</color>**: aldo-keto reductase family 1 member C1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1645|1645]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q04828|Q04828]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AKR1C1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AKR1C1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600449|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation. {ECO:0000269|PubMed:11013348, ECO:0000269|PubMed:8573067}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aldo ket red|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|androsterone dehydrogenase (B-specific) activity|
|17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|
|indanol dehydrogenase activity|
|phenanthrene 9,10-monooxygenase activity|
|response to jasmonic acid|
|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|
|cellular response to jasmonic acid stimulus|
|ketosteroid monooxygenase activity|
|bile acid binding|
|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|
|carboxylic acid binding|
|daunorubicin metabolic process|
|doxorubicin metabolic process|
|polyketide metabolic process|
|intestinal cholesterol absorption|
|steroid dehydrogenase activity|
|aminoglycoside antibiotic metabolic process|
|aldo-keto reductase (NADP) activity|
|intestinal lipid absorption|
|alcohol dehydrogenase (NADP+) activity|
|progesterone metabolic process|
|tertiary alcohol metabolic process|
|alditol:NADP+ 1-oxidoreductase activity|
|lipid digestion|
|retinal metabolic process|
|glycoside metabolic process|
|C21-steroid hormone metabolic process|
|bile acid and bile salt transport|
|quinone metabolic process|
|intestinal absorption|
|bile acid metabolic process|
|cellular aldehyde metabolic process|
|cholesterol transport|
|secondary metabolic process|
|sterol transport|
|cellular ketone metabolic process|
|digestive system process|
|primary alcohol metabolic process|
|cholesterol homeostasis|
|sterol homeostasis|
|retinoid metabolic process|
|antibiotic metabolic process|
|diterpenoid metabolic process|
|digestion|
|oxidoreductase activity|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|xenobiotic metabolic process|
|lipid homeostasis|
|glycosyl compound metabolic process|
|response to organophosphorus|
|monocarboxylic acid transport|
|isoprenoid metabolic process|
|organic hydroxy compound transport|
|cellular response to xenobiotic stimulus|
|ammonium ion metabolic process|
|hormone metabolic process|
|cellular response to acid chemical|
|steroid metabolic process|
|organic acid transport|
|carboxylic acid transport|
|lipid transport|
|response to xenobiotic stimulus|
|alcohol metabolic process|
|lipid localization|
|protein homooligomerization|
|response to acid chemical|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|organic anion transport|
|drug metabolic process|
|protein complex oligomerization|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|anion transport|
|cellular response to hormone stimulus|
|epithelial cell differentiation|
|response to hormone|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|chemical homeostasis|
|epithelium development|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|ion transport|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|homeostatic process|
|small molecule metabolic process|
|tissue development|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-2.3|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.03|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.85|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.76|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.73|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5437
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AKR1C1 Expression in NALM6 Cells: 0.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>