AKR1C2 [The Human Chemical-Genetic Interaction Map Project]

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======= AKR1C2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AKR1C2
  * **<color #00a2e8>Official Name</color>**: aldo-keto reductase family 1 member C2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1646|1646]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52895|P52895]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AKR1C2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AKR1C2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600450|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability. {ECO:0000269|PubMed:15929998, ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17442338, ECO:0000269|PubMed:8573067}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aldo ket red|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phenanthrene 9,10-monooxygenase activity|
|response to jasmonic acid|
|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|
|cellular response to jasmonic acid stimulus|
|response to prostaglandin D|
|cellular response to prostaglandin D stimulus|
|ketosteroid monooxygenase activity|
|bile acid binding|
|carboxylic acid binding|
|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|
|doxorubicin metabolic process|
|polyketide metabolic process|
|daunorubicin metabolic process|
|steroid dehydrogenase activity|
|aminoglycoside antibiotic metabolic process|
|alcohol dehydrogenase (NADP+) activity|
|progesterone metabolic process|
|tertiary alcohol metabolic process|
|alditol:NADP+ 1-oxidoreductase activity|
|glycoside metabolic process|
|cellular response to prostaglandin stimulus|
|C21-steroid hormone metabolic process|
|response to prostaglandin|
|quinone metabolic process|
|prostanoid metabolic process|
|prostaglandin metabolic process|
|secondary metabolic process|
|cellular response to fatty acid|
|cellular ketone metabolic process|
|primary alcohol metabolic process|
|response to fatty acid|
|cellular response to alcohol|
|cellular response to ketone|
|antibiotic metabolic process|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|digestion|
|oxidoreductase activity|
|cellular hormone metabolic process|
|glycosyl compound metabolic process|
|positive regulation of protein kinase B signaling|
|fatty acid derivative metabolic process|
|ammonium ion metabolic process|
|response to ketone|
|hormone metabolic process|
|cellular response to acid chemical|
|regulation of protein kinase B signaling|
|response to alcohol|
|steroid metabolic process|
|alcohol metabolic process|
|fatty acid metabolic process|
|response to acid chemical|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|drug metabolic process|
|cellular response to lipid|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|cellular response to hormone stimulus|
|epithelial cell differentiation|
|response to lipid|
|response to hormone|
|carboxylic acid metabolic process|
|positive regulation of cell population proliferation|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|epithelium development|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|small molecule metabolic process|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-2.11|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.92|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13055
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AKR1C2 Expression in NALM6 Cells: -1.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>