ALB [The Human Chemical-Genetic Interaction Map Project]

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======= ALB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALB
  * **<color #00a2e8>Official Name</color>**: albumin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=213|213]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02768|P02768]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/103600|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the most abundant protein in human blood. This protein functions in the regulation of blood plasma colloid osmotic pressure and acts as a carrier protein for a wide range of endogenous molecules including hormones, fatty acids, and metabolites, as well as exogenous drugs. Additionally, this protein exhibits an esterase-like activity with broad substrate specificity. The encoded preproprotein is proteolytically processed to generate the mature protein. A peptide derived from this protein, EPI-X4, is an endogenous inhibitor of the CXCR4 chemokine receptor. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. {ECO:0000269|PubMed:19021548}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Serum albumin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|exogenous protein binding|
|enterobactin binding|
|maintenance of mitochondrion location|
|toxic substance binding|
|maintenance of organelle location|
|negative regulation of protein oligomerization|
|high-density lipoprotein particle remodeling|
|antioxidant activity|
|fatty acid binding|
|plasma lipoprotein particle remodeling|
|protein-lipid complex remodeling|
|protein-containing complex remodeling|
|oxygen binding|
|regulation of protein oligomerization|
|plasma lipoprotein particle organization|
|mitochondrion localization|
|protein-lipid complex subunit organization|
|pyridoxal phosphate binding|
|copper ion binding|
|drug binding|
|platelet alpha granule lumen|
|regulation of plasma lipoprotein particle levels|
|retina homeostasis|
|cellular oxidant detoxification|
|maintenance of location in cell|
|cellular detoxification|
|chaperone binding|
|detoxification|
|platelet degranulation|
|negative regulation of protein complex assembly|
|blood microparticle|
|cellular response to starvation|
|maintenance of location|
|tissue homeostasis|
|response to starvation|
|cellular response to toxic substance|
|cellular response to nutrient levels|
|receptor-mediated endocytosis|
|cellular response to extracellular stimulus|
|endoplasmic reticulum lumen|
|multicellular organismal homeostasis|
|cellular response to external stimulus|
|anatomical structure homeostasis|
|post-translational protein modification|
|extracellular structure organization|
|regulation of protein complex assembly|
|response to nutrient levels|
|response to toxic substance|
|response to extracellular stimulus|
|endocytosis|
|organelle localization|
|protein-containing complex|
|import into cell|
|regulated exocytosis|
|negative regulation of cellular component organization|
|exocytosis|
|zinc ion binding|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cellular component biogenesis|
|Golgi apparatus|
|negative regulation of cell death|
|secretion by cell|
|endoplasmic reticulum|
|export from cell|
|identical protein binding|
|secretion|
|DNA binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|extracellular space|
|homeostatic process|
|regulation of cell death|
|cellular response to stress|
|protein-containing complex subunit organization|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15200
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALB Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>