ALG14 [The Human Chemical-Genetic Interaction Map Project]

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======= ALG14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALG14
  * **<color #00a2e8>Official Name</color>**: ALG14 UDP-N-acetylglucosaminyltransferase subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=199857|199857]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96F25|Q96F25]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALG14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALG14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612866|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the glycosyltransferase 1 family. The encoded protein and ALG13 are thought to be subunits of UDP-GlcNAc transferase, which catalyzes the first two committed steps in endoplasmic reticulum N-linked glycosylation. Mutations in this gene have been linked to congenital myasthenic syndrome (CMSWTA). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER. {ECO:0000269|PubMed:16100110}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Alg14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity|
|UDP-N-acetylglucosamine transferase complex|
|dolichol-linked oligosaccharide biosynthetic process|
|oligosaccharide-lipid intermediate biosynthetic process|
|protein N-linked glycosylation|
|nuclear membrane|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate derivative biosynthetic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.87|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.79|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.75|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.71|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.73|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pmm2|PMM2]]|0.588|
|[[:human genes:d:dpagt1|DPAGT1]]|0.575|
|[[:human genes:r:rtcb|RTCB]]|0.566|
|[[:human genes:h:hars|HARS]]|0.562|
|[[:human genes:t:triap1|TRIAP1]]|0.532|
|[[:human genes:t:thg1l|THG1L]]|0.519|
|[[:human genes:g:gmppb|GMPPB]]|0.513|
|[[:human genes:r:rnmt|RNMT]]|0.509|
|[[:human genes:g:gfpt1|GFPT1]]|0.504|
|[[:human genes:e:eprs|EPRS]]|0.496|
|[[:human genes:d:ddx20|DDX20]]|0.496|
|[[:human genes:t:tti2|TTI2]]|0.494|
|[[:human genes:e:exoc4|EXOC4]]|0.49|
|[[:human genes:m:med16|MED16]]|0.488|
|[[:human genes:a:alg1|ALG1]]|0.483|
|[[:human genes:a:atxn10|ATXN10]]|0.482|
|[[:human genes:g:gemin5|GEMIN5]]|0.481|
|[[:human genes:a:aars|AARS]]|0.48|
|[[:human genes:n:nae1|NAE1]]|0.476|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.473|
|[[:human genes:p:pelo|PELO]]|0.473|
|[[:human genes:c:ccdc101|CCDC101]]|0.47|
|[[:human genes:u:uap1|UAP1]]|0.467|
|[[:human genes:o:otud5|OTUD5]]|0.462|
|[[:human genes:c:csnk2b|CSNK2B]]|0.461|
|[[:human genes:v:vezt|VEZT]]|0.46|
|[[:human genes:a:alg5|ALG5]]|0.458|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.458|
|[[:human genes:t:tbca|TBCA]]|0.456|
|[[:human genes:n:nars|NARS]]|0.451|
|[[:human genes:r:rpe|RPE]]|0.451|
|[[:human genes:c:cct7|CCT7]]|0.451|
|[[:human genes:d:dad1|DAD1]]|0.45|
|[[:human genes:r:rpp21|RPP21]]|0.45|
|[[:human genes:y:yars|YARS]]|0.45|
|[[:human genes:a:adsl|ADSL]]|0.449|
|[[:human genes:e:eif4e|EIF4E]]|0.448|
|[[:human genes:t:trmt5|TRMT5]]|0.447|
|[[:human genes:d:ddost|DDOST]]|0.447|
|[[:human genes:m:meaf6|MEAF6]]|0.445|
|[[:human genes:n:nsmce1|NSMCE1]]|0.442|
|[[:human genes:r:rptor|RPTOR]]|0.441|
|[[:human genes:h:hspd1|HSPD1]]|0.44|
|[[:human genes:a:alg2|ALG2]]|0.436|
|[[:human genes:s:srp14|SRP14]]|0.436|
|[[:human genes:a:alg13|ALG13]]|0.435|
|[[:human genes:i:iars2|IARS2]]|0.432|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.431|
|[[:human genes:g:gnb1l|GNB1L]]|0.427|
|[[:human genes:s:srp68|SRP68]]|0.425|
|[[:human genes:z:zrsr2|ZRSR2]]|0.422|
|[[:human genes:s:srp72|SRP72]]|0.421|
|[[:human genes:s:spcs2|SPCS2]]|0.42|
|[[:human genes:m:mars|MARS]]|0.42|
|[[:human genes:t:telo2|TELO2]]|0.419|
|[[:human genes:t:timm13|TIMM13]]|0.419|
|[[:human genes:r:rbm14|RBM14]]|0.418|
|[[:human genes:e:eny2|ENY2]]|0.418|
|[[:human genes:d:dohh|DOHH]]|0.417|
|[[:human genes:t:tsen34|TSEN34]]|0.416|
|[[:human genes:u:utp23|UTP23]]|0.416|
|[[:human genes:p:polr3h|POLR3H]]|0.415|
|[[:human genes:p:pam16|PAM16]]|0.412|
|[[:human genes:u:uxt|UXT]]|0.412|
|[[:human genes:b:bap1|BAP1]]|0.411|
|[[:human genes:v:vrk1|VRK1]]|0.409|
|[[:human genes:v:vmp1|VMP1]]|0.409|
|[[:human genes:a:alg6|ALG6]]|0.408|
|[[:human genes:o:osgep|OSGEP]]|0.408|
|[[:human genes:d:dolk|DOLK]]|0.404|
|[[:human genes:d:dhdds|DHDDS]]|0.404|
|[[:human genes:s:slc35b1|SLC35B1]]|0.404|
|[[:human genes:t:tgs1|TGS1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 579/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|18/28|
|bone|21/26|
|breast|21/33|
|central nervous system|50/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|17/21|
|liver|17/20|
|lung|61/75|
|lymphocyte|7/16|
|ovary|21/26|
|pancreas|23/24|
|peripheral nervous system|13/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|18/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|23/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1554
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALG14 Expression in NALM6 Cells: 5.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>