ALG1L2 [The Human Chemical-Genetic Interaction Map Project]

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======= ALG1L2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALG1L2
  * **<color #00a2e8>Official Name</color>**: ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=644974|644974]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/C9J202|C9J202]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALG1L2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALG1L2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Putative glycosyltransferase. {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mannosyltransferase activity|
|mannosylation|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate derivative biosynthetic process|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.34|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.19|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.1|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.97|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.81|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.78|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.77|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15210
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALG1L2 Expression in NALM6 Cells: 1.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>