ALG8 [The Human Chemical-Genetic Interaction Map Project]

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======= ALG8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALG8
  * **<color #00a2e8>Official Name</color>**: ALG8 alpha-1,3-glucosyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79053|79053]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BVK2|Q9BVK2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALG8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALG8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608103|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation of proteins. Mutations in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ih). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Alg6 Alg8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity|
|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity|
|alpha-1,3-mannosyltransferase activity|
|dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity|
|dolichol-linked oligosaccharide biosynthetic process|
|oligosaccharide-lipid intermediate biosynthetic process|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|mannosylation|
|protein N-linked glycosylation|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate derivative biosynthetic process|
|peptidyl-amino acid modification|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-2.01|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.84|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.72|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.7|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.79|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.02|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.13|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:alg6|ALG6]]|0.658|
|[[:human genes:d:dhrsx|DHRSX]]|0.604|
|[[:human genes:s:srd5a3|SRD5A3]]|0.56|
|[[:human genes:m:mbtps2|MBTPS2]]|0.505|
|[[:human genes:s:sec62|SEC62]]|0.499|
|[[:human genes:u:uba5|UBA5]]|0.494|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.492|
|[[:human genes:m:mrps6|MRPS6]]|0.486|
|[[:human genes:m:mrpl23|MRPL23]]|0.476|
|[[:human genes:y:yars2|YARS2]]|0.475|
|[[:human genes:d:dap3|DAP3]]|0.47|
|[[:human genes:r:rpia|RPIA]]|0.467|
|[[:human genes:p:pgm3|PGM3]]|0.465|
|[[:human genes:p:pars2|PARS2]]|0.464|
|[[:human genes:d:dolk|DOLK]]|0.461|
|[[:human genes:c:c1orf27|C1orf27]]|0.46|
|[[:human genes:c:c10orf2|C10orf2]]|0.453|
|[[:human genes:m:mrps5|MRPS5]]|0.451|
|[[:human genes:p:pmm2|PMM2]]|0.45|
|[[:human genes:s:selrc1|SELRC1]]|0.449|
|[[:human genes:p:pmvk|PMVK]]|0.446|
|[[:human genes:t:trmt61a|TRMT61A]]|0.444|
|[[:human genes:u:uso1|USO1]]|0.442|
|[[:human genes:s:sec63|SEC63]]|0.441|
|[[:human genes:c:chchd4|CHCHD4]]|0.441|
|[[:human genes:r:rft1|RFT1]]|0.439|
|[[:human genes:u:ufc1|UFC1]]|0.439|
|[[:human genes:s:ssb|SSB]]|0.439|
|[[:human genes:a:alg1|ALG1]]|0.438|
|[[:human genes:s:srp14|SRP14]]|0.438|
|[[:human genes:a:alg13|ALG13]]|0.436|
|[[:human genes:p:polg|POLG]]|0.436|
|[[:human genes:f:fastkd5|FASTKD5]]|0.436|
|[[:human genes:m:mpdu1|MPDU1]]|0.435|
|[[:human genes:d:dpm1|DPM1]]|0.434|
|[[:human genes:d:dpagt1|DPAGT1]]|0.434|
|[[:human genes:m:mrps24|MRPS24]]|0.433|
|[[:human genes:m:manf|MANF]]|0.429|
|[[:human genes:m:mrpl15|MRPL15]]|0.428|
|[[:human genes:d:dpm3|DPM3]]|0.427|
|[[:human genes:m:mrpl11|MRPL11]]|0.427|
|[[:human genes:c:c17orf89|C17orf89]]|0.426|
|[[:human genes:a:alg5|ALG5]]|0.425|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.424|
|[[:human genes:s:sco2|SCO2]]|0.423|
|[[:human genes:d:dnajb11|DNAJB11]]|0.422|
|[[:human genes:a:atxn10|ATXN10]]|0.421|
|[[:human genes:p:pgs1|PGS1]]|0.419|
|[[:human genes:m:mrps14|MRPS14]]|0.417|
|[[:human genes:m:mrpl21|MRPL21]]|0.417|
|[[:human genes:d:dars2|DARS2]]|0.416|
|[[:human genes:m:mrpl53|MRPL53]]|0.416|
|[[:human genes:d:dnajc3|DNAJC3]]|0.415|
|[[:human genes:t:triap1|TRIAP1]]|0.415|
|[[:human genes:c:cox16|COX16]]|0.412|
|[[:human genes:t:trmt6|TRMT6]]|0.412|
|[[:human genes:t:trmt10a|TRMT10A]]|0.412|
|[[:human genes:t:tamm41|TAMM41]]|0.409|
|[[:human genes:u:uap1|UAP1]]|0.408|
|[[:human genes:t:timm8b|TIMM8B]]|0.408|
|[[:human genes:q:qrsl1|QRSL1]]|0.408|
|[[:human genes:b:bcs1l|BCS1L]]|0.408|
|[[:human genes:r:romo1|ROMO1]]|0.408|
|[[:human genes:t:tars2|TARS2]]|0.406|
|[[:human genes:n:nars2|NARS2]]|0.406|
|[[:human genes:s:sars2|SARS2]]|0.405|
|[[:human genes:m:mrps18a|MRPS18A]]|0.404|
|[[:human genes:r:rpusd4|RPUSD4]]|0.404|
|[[:human genes:l:lars2|LARS2]]|0.402|
|[[:human genes:m:mrps33|MRPS33]]|0.402|
|[[:human genes:v:vars2|VARS2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2847
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALG8 Expression in NALM6 Cells: 5.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>