ALKBH5 [The Human Chemical-Genetic Interaction Map Project]

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======= ALKBH5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALKBH5
  * **<color #00a2e8>Official Name</color>**: alkB homolog 5, RNA demethylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54890|54890]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6P6C2|Q6P6C2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALKBH5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALKBH5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613303|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Can also demethylate N(6)- methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA N6-methyladenosine dioxygenase activity|
|oxidative single-stranded RNA demethylation|
|oxidative RNA demethylation|
|DNA dealkylation involved in DNA repair|
|2-oxoglutarate-dependent dioxygenase activity|
|oxidative demethylation|
|DNA dealkylation|
|demethylation|
|DNA modification|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|RNA modification|
|regulation of mRNA stability|
|regulation of RNA stability|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|regulation of mRNA catabolic process|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|regulation of mRNA metabolic process|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|nuclear speck|
|mRNA processing|
|DNA repair|
|posttranscriptional regulation of gene expression|
|spermatogenesis|
|male gamete generation|
|gamete generation|
|mRNA metabolic process|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|RNA processing|
|oxidation-reduction process|
|Golgi apparatus|
|intracellular protein transport|
|regulation of catabolic process|
|multi-organism reproductive process|
|response to abiotic stimulus|
|RNA binding|
|reproductive process|
|reproduction|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-4.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5379
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALKBH5 Expression in NALM6 Cells: 6.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>