AMELX [The Human Chemical-Genetic Interaction Map Project]

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======= AMELX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AMELX
  * **<color #00a2e8>Official Name</color>**: amelogenin X-linked
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=265|265]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99217|Q99217]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AMELX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AMELX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300391|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Amelogenin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hydroxyapatite binding|
|positive regulation of tooth mineralization|
|structural constituent of tooth enamel|
|regulation of tooth mineralization|
|positive regulation of odontogenesis|
|enamel mineralization|
|tooth mineralization|
|amelogenesis|
|positive regulation of collagen biosynthetic process|
|regulation of odontogenesis|
|positive regulation of collagen metabolic process|
|regulation of collagen biosynthetic process|
|regulation of collagen metabolic process|
|positive regulation of biomineral tissue development|
|positive regulation of biomineralization|
|endocytic vesicle|
|epithelial to mesenchymal transition|
|positive regulation of animal organ morphogenesis|
|odontogenesis of dentin-containing tooth|
|chondrocyte differentiation|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|biomineralization|
|biomineral tissue development|
|odontogenesis|
|osteoblast differentiation|
|response to calcium ion|
|mesenchymal cell differentiation|
|growth factor activity|
|cartilage development|
|response to nutrient|
|mesenchyme development|
|connective tissue development|
|regulation of animal organ morphogenesis|
|ossification|
|endoplasmic reticulum lumen|
|post-translational protein modification|
|collagen-containing extracellular matrix|
|response to metal ion|
|skeletal system development|
|response to nutrient levels|
|response to extracellular stimulus|
|response to inorganic substance|
|cell surface|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|Golgi apparatus|
|response to drug|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|positive regulation of developmental process|
|regulation of cell population proliferation|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.78|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.75|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.97|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.05|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2.29|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14850
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AMELX Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>