ANAPC1 [The Human Chemical-Genetic Interaction Map Project]

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======= ANAPC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANAPC1
  * **<color #00a2e8>Official Name</color>**: anaphase promoting complex subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64682|64682]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H1A4|Q9H1A4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANAPC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANAPC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608473|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Apc1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|metaphase/anaphase transition of cell cycle|
|metaphase/anaphase transition of mitotic cell cycle|
|anaphase-promoting complex|
|protein K11-linked ubiquitination|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|regulation of sister chromatid segregation|
|anaphase-promoting complex-dependent catabolic process|
|regulation of chromosome segregation|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|ubiquitin protein ligase activity|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|regulation of chromosome organization|
|proteasomal protein catabolic process|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|cell division|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|protein catabolic process|
|mitotic cell cycle|
|protein ubiquitination|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of cell cycle|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.92|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.86|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 394/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|16/28|
|blood|13/28|
|bone|15/26|
|breast|21/33|
|central nervous system|37/56|
|cervix|3/4|
|colorectal|8/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|7/16|
|kidney|12/21|
|liver|12/20|
|lung|39/75|
|lymphocyte|4/16|
|ovary|14/26|
|pancreas|6/24|
|peripheral nervous system|6/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|10/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|9/22|
|urinary tract|14/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2577
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANAPC1 Expression in NALM6 Cells: 7.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>