ANAPC2 [The Human Chemical-Genetic Interaction Map Project]

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======= ANAPC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANAPC2
  * **<color #00a2e8>Official Name</color>**: anaphase promoting complex subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29882|29882]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UJX6|Q9UJX6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANAPC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANAPC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606946|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. {ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|APC2|
|Cullin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of synapse maturation|
|positive regulation of synaptic plasticity|
|regulation of synapse maturation|
|anaphase-promoting complex|
|protein K11-linked ubiquitination|
|positive regulation of dendrite morphogenesis|
|positive regulation of axon extension|
|positive regulation of dendrite development|
|anaphase-promoting complex-dependent catabolic process|
|positive regulation of axonogenesis|
|regulation of dendrite morphogenesis|
|regulation of axon extension|
|regulation of extent of cell growth|
|regulation of dendrite development|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|regulation of cell size|
|regulation of axonogenesis|
|regulation of synaptic plasticity|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|positive regulation of growth|
|positive regulation of neuron projection development|
|ubiquitin protein ligase binding|
|protein polyubiquitination|
|regulation of cell morphogenesis involved in differentiation|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|regulation of developmental growth|
|proteasomal protein catabolic process|
|positive regulation of neuron differentiation|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of cell cycle phase transition|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|cell division|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|positive regulation of nervous system development|
|positive regulation of cell development|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|regulation of neuron differentiation|
|regulation of growth|
|protein catabolic process|
|protein ubiquitination|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|regulation of neurogenesis|
|cellular macromolecule catabolic process|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|proteolysis|
|cell cycle|
|positive regulation of developmental process|
|generation of neurons|
|neurogenesis|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-2.31|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-2.11|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.79|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.487|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 718/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|28/28|
|bone|25/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|19/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|22/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1411
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANAPC2 Expression in NALM6 Cells: 6.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>