ANG [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= ANG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANG
  * **<color #00a2e8>Official Name</color>**: angiogenin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=283|283]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P03950|P03950]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/105850|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. {ECO:0000269|PubMed:12051708, ECO:0000269|PubMed:1400510, ECO:0000269|PubMed:19354288, ECO:0000269|PubMed:21855800}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RnaseA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|angiogenin-PRI complex|
|diacylglycerol biosynthetic process|
|activation of phospholipase A2 activity|
|positive regulation of phospholipase A2 activity|
|regulation of phospholipase A2 activity|
|oocyte maturation|
|rRNA transcription|
|ribonuclease activity|
|acylglycerol biosynthetic process|
|neutral lipid biosynthetic process|
|diacylglycerol metabolic process|
|actin filament polymerization|
|activation of phospholipase C activity|
|activation of protein kinase B activity|
|rRNA binding|
|oocyte development|
|endonuclease activity|
|positive regulation of phospholipase C activity|
|oocyte differentiation|
|negative regulation of smooth muscle cell proliferation|
|regulation of phospholipase C activity|
|actin polymerization or depolymerization|
|ovarian follicle development|
|peptide binding|
|copper ion binding|
|positive regulation of phospholipase activity|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|oogenesis|
|adherens junction organization|
|protein polymerization|
|female gonad development|
|basement membrane|
|development of primary female sexual characteristics|
|positive regulation of endothelial cell proliferation|
|ncRNA transcription|
|regulation of lipase activity|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|female sex differentiation|
|regulation of endothelial cell proliferation|
|growth cone|
|negative regulation of translation|
|female gamete generation|
|regulation of smooth muscle cell proliferation|
|anatomical structure maturation|
|negative regulation of cellular amide metabolic process|
|placenta development|
|cell maturation|
|RNA phosphodiester bond hydrolysis|
|heparin binding|
|positive regulation of epithelial cell proliferation|
|gonad development|
|cell junction organization|
|development of primary sexual characteristics|
|glycerolipid biosynthetic process|
|actin filament organization|
|developmental maturation|
|cytoplasmic vesicle|
|germ cell development|
|sex differentiation|
|actin binding|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|nucleic acid phosphodiester bond hydrolysis|
|angiogenesis|
|activation of protein kinase activity|
|regulation of epithelial cell proliferation|
|signaling receptor binding|
|response to hypoxia|
|regulation of translation|
|cellular process involved in reproduction in multicellular organism|
|response to decreased oxygen levels|
|neuronal cell body|
|glycerolipid metabolic process|
|response to oxygen levels|
|regulation of cellular amide metabolic process|
|positive regulation of secretion by cell|
|blood vessel morphogenesis|
|positive regulation of protein transport|
|reproductive structure development|
|reproductive system development|
|positive regulation of secretion|
|supramolecular fiber organization|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|blood vessel development|
|actin cytoskeleton organization|
|regulation of peptide secretion|
|vasculature development|
|cardiovascular system development|
|posttranscriptional regulation of gene expression|
|positive regulation of protein kinase activity|
|actin filament-based process|
|positive regulation of kinase activity|
|lipid biosynthetic process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|tube morphogenesis|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|gamete generation|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|regulation of secretion|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|tube development|
|nucleolus|
|circulatory system development|
|regulation of kinase activity|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|positive regulation of cell population proliferation|
|cellular lipid metabolic process|
|cell migration|
|regulation of transferase activity|
|positive regulation of transport|
|multi-organism reproductive process|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|organic cyclic compound biosynthetic process|
|locomotion|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cell development|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|extracellular region|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.451|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3349
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANG Expression in NALM6 Cells: -0.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>