ANGPT1 [The Human Chemical-Genetic Interaction Map Project]

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======= ANGPT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANGPT1
  * **<color #00a2e8>Official Name</color>**: angiopoietin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=284|284]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15389|Q15389]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANGPT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANGPT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601667|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. {ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120, ECO:0000269|PubMed:9204896}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fibrinogen C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of macrophage migration inhibitory factor signaling pathway|
|Tie signaling pathway|
|negative regulation of cytokine secretion involved in immune response|
|heparin biosynthetic process|
|heparin metabolic process|
|negative regulation of protein import into nucleus|
|negative regulation of protein import|
|negative regulation of vascular permeability|
|regulation of skeletal muscle satellite cell proliferation|
|activation of transmembrane receptor protein tyrosine kinase activity|
|regulation of skeletal muscle cell proliferation|
|regulation of cytokine secretion involved in immune response|
|glomerulus vasculature development|
|renal system vasculature development|
|kidney vasculature development|
|negative regulation of nucleocytoplasmic transport|
|negative regulation of cytokine production involved in immune response|
|protein localization to cell surface|
|positive regulation of receptor internalization|
|negative regulation of protein localization to nucleus|
|negative regulation of endothelial cell apoptotic process|
|negative regulation of production of molecular mediator of immune response|
|regulation of vascular permeability|
|negative regulation of intracellular protein transport|
|negative regulation of epithelial cell apoptotic process|
|positive chemotaxis|
|regulation of endothelial cell apoptotic process|
|glomerulus development|
|positive regulation of receptor-mediated endocytosis|
|regulation of receptor internalization|
|regulation of protein import into nucleus|
|positive regulation of blood vessel endothelial cell migration|
|receptor tyrosine kinase binding|
|sprouting angiogenesis|
|regulation of protein import|
|negative regulation of intracellular transport|
|microvillus|
|negative regulation of cytokine secretion|
|regulation of epithelial cell apoptotic process|
|regulation of cytokine production involved in immune response|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|regulation of blood vessel endothelial cell migration|
|positive regulation of endothelial cell migration|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|glycosaminoglycan biosynthetic process|
|positive regulation of peptidyl-serine phosphorylation|
|regulation of nucleocytoplasmic transport|
|mucopolysaccharide metabolic process|
|aminoglycan biosynthetic process|
|negative regulation of cellular protein localization|
|positive regulation of protein ubiquitination|
|regulation of protein localization to nucleus|
|regulation of phosphatidylinositol 3-kinase signaling|
|negative regulation of immune effector process|
|nephron development|
|regulation of endothelial cell proliferation|
|negative regulation of protein secretion|
|positive regulation of protein modification by small protein conjugation or removal|
|regulation of peptidyl-serine phosphorylation|
|negative regulation of peptide secretion|
|regulation of production of molecular mediator of immune response|
|positive regulation of epithelial cell migration|
|negative regulation of neuron apoptotic process|
|negative regulation of immune response|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|glycosaminoglycan metabolic process|
|regulation of endothelial cell migration|
|regulation of cytokine-mediated signaling pathway|
|aminoglycan metabolic process|
|positive regulation of protein kinase B signaling|
|vascular process in circulatory system|
|regulation of response to cytokine stimulus|
|negative regulation of protein transport|
|sulfur compound biosynthetic process|
|cell-substrate adhesion|
|negative regulation of establishment of protein localization|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of protein ubiquitination|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of endocytosis|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of protein binding|
|regulation of protein kinase B signaling|
|regulation of epithelial cell migration|
|membrane raft|
|regulation of protein modification by small protein conjugation or removal|
|regulation of intracellular protein transport|
|negative regulation of secretion|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of peptidyl-tyrosine phosphorylation|
|kidney development|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|renal system development|
|regulation of ERK1 and ERK2 cascade|
|regulation of neuron death|
|angiogenesis|
|urogenital system development|
|activation of protein kinase activity|
|regulation of epithelial cell proliferation|
|regulation of intracellular transport|
|sulfur compound metabolic process|
|MAPK cascade|
|regulation of binding|
|in utero embryonic development|
|leukocyte migration|
|blood circulation|
|signal transduction by protein phosphorylation|
|circulatory system process|
|positive regulation of cell adhesion|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of protein secretion|
|regulation of immune effector process|
|negative regulation of transport|
|blood vessel development|
|regulation of peptide secretion|
|positive regulation of cell migration|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cardiovascular system development|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|hematopoietic or lymphoid organ development|
|carbohydrate derivative biosynthetic process|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of secretion|
|cellular protein-containing complex assembly|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|embryo development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|negative regulation of cell death|
|oxoacid metabolic process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|negative regulation of protein metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|phosphorylation|
|locomotion|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|extracellular space|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.74|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|2.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19018
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANGPT1 Expression in NALM6 Cells: -0.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>