ANGPT2 [The Human Chemical-Genetic Interaction Map Project]

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======= ANGPT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANGPT2
  * **<color #00a2e8>Official Name</color>**: angiopoietin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=285|285]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15123|O15123]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANGPT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANGPT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601922|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. {ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:19116766, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:9204896}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fibrinogen C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of positive chemotaxis|
|Tie signaling pathway|
|glomerulus vasculature development|
|kidney vasculature development|
|renal system vasculature development|
|regulation of positive chemotaxis|
|negative regulation of blood vessel endothelial cell migration|
|negative regulation of endothelial cell migration|
|glomerulus development|
|receptor tyrosine kinase binding|
|negative regulation of chemotaxis|
|negative regulation of cell-substrate adhesion|
|maternal process involved in female pregnancy|
|response to activity|
|negative regulation of epithelial cell migration|
|animal organ regeneration|
|regulation of blood vessel endothelial cell migration|
|cell projection|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|nephron development|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|regeneration|
|regulation of endothelial cell migration|
|positive regulation of angiogenesis|
|response to carbohydrate|
|female pregnancy|
|positive regulation of vasculature development|
|multi-multicellular organism process|
|regulation of cell-substrate adhesion|
|regulation of chemotaxis|
|response to mechanical stimulus|
|regulation of epithelial cell migration|
|germ cell development|
|negative regulation of cell migration|
|kidney development|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|renal system development|
|regulation of angiogenesis|
|negative regulation of cellular component movement|
|angiogenesis|
|urogenital system development|
|regulation of vasculature development|
|negative regulation of locomotion|
|signaling receptor binding|
|response to hypoxia|
|cellular process involved in reproduction in multicellular organism|
|response to decreased oxygen levels|
|negative regulation of response to external stimulus|
|leukocyte migration|
|response to oxygen levels|
|blood vessel morphogenesis|
|response to radiation|
|blood vessel development|
|cellular response to growth factor stimulus|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cardiovascular system development|
|response to growth factor|
|tube morphogenesis|
|developmental process involved in reproduction|
|regulation of cell adhesion|
|gamete generation|
|enzyme linked receptor protein signaling pathway|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|response to organic cyclic compound|
|negative regulation of developmental process|
|cell migration|
|regulation of locomotion|
|multi-organism reproductive process|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|locomotion|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|extracellular space|
|negative regulation of response to stimulus|
|cell development|
|positive regulation of multicellular organismal process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.71|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|1.77|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14104
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANGPT2 Expression in NALM6 Cells: 3.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>