ANK2 [The Human Chemical-Genetic Interaction Map Project]

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======= ANK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANK2
  * **<color #00a2e8>Official Name</color>**: ankyrin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=287|287]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01484|Q01484]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/106410|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors (By similarity). Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3- phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|Ank|
|Death|
|ZU5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to T-tubule|
|regulation of SA node cell action potential|
|protein localization to M-band|
|phosphorylation-dependent protein binding|
|membrane depolarization during SA node cell action potential|
|response to methylmercury|
|regulation of atrial cardiac muscle cell action potential|
|paranodal junction assembly|
|SA node cell to atrial cardiac muscle cell signaling|
|SA node cell action potential|
|T-tubule organization|
|SA node cell to atrial cardiac muscle cell communication|
|A band|
|atrial cardiac muscle cell to AV node cell signaling|
|atrial cardiac muscle cell action potential|
|sarcoplasmic reticulum calcium ion transport|
|atrial cardiac muscle cell to AV node cell communication|
|membrane depolarization during cardiac muscle cell action potential|
|myelin assembly|
|costamere|
|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|
|axon initial segment|
|atrial septum development|
|ventricular cardiac muscle cell action potential|
|regulation of ventricular cardiac muscle cell membrane repolarization|
|positive regulation of potassium ion transmembrane transporter activity|
|regulation of cardiac muscle contraction by calcium ion signaling|
|protein localization to cell surface|
|regulation of cardiac muscle cell membrane repolarization|
|cell-cell signaling involved in cardiac conduction|
|M band|
|spectrin binding|
|regulation of cardiac muscle cell action potential|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|membrane depolarization during action potential|
|regulation of membrane repolarization|
|cardiac atrium development|
|regulation of cardiac muscle cell contraction|
|regulation of heart rate by cardiac conduction|
|positive regulation of potassium ion transmembrane transport|
|positive regulation of calcium ion transmembrane transporter activity|
|cardiac muscle cell action potential involved in contraction|
|regulation of actin filament-based movement|
|cardiac muscle cell contraction|
|T-tubule|
|cell communication involved in cardiac conduction|
|positive regulation of potassium ion transport|
|intercalated disc|
|regulation of action potential|
|cardiac muscle cell action potential|
|membrane depolarization|
|regulation of potassium ion transmembrane transporter activity|
|regulation of cardiac conduction|
|positive regulation of cation channel activity|
|positive regulation of calcium ion transmembrane transport|
|regulation of cardiac muscle contraction|
|regulation of release of sequestered calcium ion into cytosol|
|cardiac muscle contraction|
|protein binding, bridging|
|regulation of potassium ion transmembrane transport|
|ATPase binding|
|heart contraction|
|regulation of calcium ion transmembrane transporter activity|
|actin-mediated cell contraction|
|regulation of striated muscle contraction|
|cardiac conduction|
|plasma membrane organization|
|action potential|
|regulation of potassium ion transport|
|regulation of heart rate|
|regulation of calcium ion transport into cytosol|
|sarcolemma|
|heart process|
|structural constituent of cytoskeleton|
|positive regulation of ion transmembrane transporter activity|
|cellular component assembly involved in morphogenesis|
|cell-cell junction assembly|
|myelination|
|axon ensheathment|
|ensheathment of neurons|
|striated muscle contraction|
|cardiac septum development|
|actin filament-based movement|
|positive regulation of transporter activity|
|recycling endosome|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|ion channel binding|
|Z disc|
|multicellular organismal signaling|
|protein localization to endoplasmic reticulum|
|cell-cell junction organization|
|positive regulation of cation transmembrane transport|
|calcium-mediated signaling|
|regulation of calcium ion transmembrane transport|
|muscle cell development|
|positive regulation of ion transmembrane transport|
|regulation of muscle contraction|
|cell junction assembly|
|cardiac chamber development|
|regulation of cation channel activity|
|protein stabilization|
|protein localization to plasma membrane|
|basolateral plasma membrane|
|postsynaptic membrane|
|positive regulation of transmembrane transport|
|cell junction organization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|membrane raft|
|protein localization to cell periphery|
|regulation of muscle system process|
|regulation of heart contraction|
|muscle cell differentiation|
|regulation of calcium ion transport|
|calcium ion transport|
|muscle contraction|
|lysosome|
|early endosome|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of protein stability|
|regulation of blood circulation|
|divalent metal ion transport|
|muscle system process|
|divalent inorganic cation transport|
|apical plasma membrane|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|enzyme binding|
|cytoskeleton|
|Golgi vesicle transport|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|endomembrane system organization|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|protein kinase binding|
|cellular divalent inorganic cation homeostasis|
|muscle structure development|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|divalent inorganic cation homeostasis|
|heart development|
|endocytosis|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|actin filament-based process|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|import into cell|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|protein localization to organelle|
|cellular chemical homeostasis|
|ion homeostasis|
|cellular component morphogenesis|
|cation transport|
|membrane organization|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|regulation of cellular localization|
|positive regulation of transport|
|regulation of cellular component movement|
|cytoskeleton organization|
|chemical homeostasis|
|cell-cell signaling|
|mitochondrion|
|ion transport|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|cell development|
|intracellular signal transduction|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|system process|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.71|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.73|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.84|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15425
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANK2 Expression in NALM6 Cells: -0.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>