ANKLE2 [The Human Chemical-Genetic Interaction Map Project]

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======= ANKLE2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANKLE2
  * **<color #00a2e8>Official Name</color>**: ankyrin repeat and LEM domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23141|23141]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86XL3|Q86XL3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANKLE2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANKLE2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616062|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause morphology defects in the nuclear envelope and BAF hyperphosphorylation. [provided by RefSeq, Mar 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|LEM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic nuclear envelope reassembly|
|nuclear envelope reassembly|
|protein phosphatase 2A binding|
|protein phosphatase regulator activity|
|positive regulation of protein dephosphorylation|
|nuclear envelope organization|
|positive regulation of dephosphorylation|
|integral component of endoplasmic reticulum membrane|
|regulation of phosphoprotein phosphatase activity|
|nucleus organization|
|regulation of protein dephosphorylation|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|endomembrane system organization|
|negative regulation of phosphorylation|
|cell division|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|mitotic cell cycle process|
|mitotic cell cycle|
|membrane organization|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|endoplasmic reticulum membrane|
|central nervous system development|
|negative regulation of cell death|
|cell cycle process|
|endoplasmic reticulum|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|cell cycle|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.82|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.81|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|1.72|
|[[:results:exp302|35°C R06 exp302]]|1.73|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.75|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.79|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.8|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.86|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.95|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.98|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|2.23|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.28|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:ticrr|TICRR]]|0.553|
|[[:human genes:t:tceb3c|TCEB3C]]|0.551|
|[[:human genes:c:chd4|CHD4]]|0.545|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.541|
|[[:human genes:s:supt6h|SUPT6H]]|0.539|
|[[:human genes:p:psmb4|PSMB4]]|0.538|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.532|
|[[:human genes:c:cbwd3|CBWD3]]|0.531|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.522|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.521|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.517|
|[[:human genes:n:nupl1|NUPL1]]|0.516|
|[[:human genes:o:or10g3|OR10G3]]|0.514|
|[[:human genes:k:kctd17|KCTD17]]|0.513|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.513|
|[[:human genes:c:chaf1a|CHAF1A]]|0.509|
|[[:human genes:a:arcn1|ARCN1]]|0.502|
|[[:human genes:p:pan3|PAN3]]|0.5|
|[[:human genes:d:dock6|DOCK6]]|0.497|
|[[:human genes:z:zfand5|ZFAND5]]|0.496|
|[[:human genes:c:cbwd6|CBWD6]]|0.495|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.494|
|[[:human genes:r:rps2|RPS2]]|0.492|
|[[:human genes:c:cbwd5|CBWD5]]|0.489|
|[[:human genes:s:sec13|SEC13]]|0.489|
|[[:human genes:p:psmd3|PSMD3]]|0.484|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.483|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.482|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.482|
|[[:human genes:p:polr2j3|POLR2J3]]|0.481|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.481|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.481|
|[[:human genes:p:pola1|POLA1]]|0.481|
|[[:human genes:c:cdc73|CDC73]]|0.48|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.48|
|[[:human genes:p:paf1|PAF1]]|0.478|
|[[:human genes:s:smg1|SMG1]]|0.477|
|[[:human genes:c:ccna2|CCNA2]]|0.476|
|[[:human genes:r:rad21|RAD21]]|0.476|
|[[:human genes:e:exosc9|EXOSC9]]|0.475|
|[[:human genes:m:med17|MED17]]|0.475|
|[[:human genes:d:ddtl|DDTL]]|0.475|
|[[:human genes:s:supt5h|SUPT5H]]|0.475|
|[[:human genes:p:psmc6|PSMC6]]|0.473|
|[[:human genes:n:npipb5|NPIPB5]]|0.47|
|[[:human genes:p:psmd1|PSMD1]]|0.467|
|[[:human genes:s:ssh2|SSH2]]|0.465|
|[[:human genes:v:vasn|VASN]]|0.464|
|[[:human genes:x:xylt2|XYLT2]]|0.462|
|[[:human genes:d:dtl|DTL]]|0.462|
|[[:human genes:g:gprin2|GPRIN2]]|0.462|
|[[:human genes:e:exosc5|EXOSC5]]|0.462|
|[[:human genes:d:disp2|DISP2]]|0.461|
|[[:human genes:c:cactin|CACTIN]]|0.46|
|[[:human genes:h:hap1|HAP1]]|0.46|
|[[:human genes:t:tsg101|TSG101]]|0.459|
|[[:human genes:c:chmp4b|CHMP4B]]|0.458|
|[[:human genes:c:c14orf93|C14orf93]]|0.457|
|[[:human genes:o:orc1|ORC1]]|0.456|
|[[:human genes:c:copb2|COPB2]]|0.456|
|[[:human genes:s:smg7|SMG7]]|0.455|
|[[:human genes:c:copb1|COPB1]]|0.455|
|[[:human genes:f:fbxw9|FBXW9]]|0.454|
|[[:human genes:w:wdr75|WDR75]]|0.453|
|[[:human genes:f:fam231c|FAM231C]]|0.451|
|[[:human genes:p:psmc1|PSMC1]]|0.451|
|[[:human genes:b:bysl|BYSL]]|0.451|
|[[:human genes:f:fam231a|FAM231A]]|0.451|
|[[:human genes:t:twistnb|TWISTNB]]|0.45|
|[[:human genes:a:akirin2|AKIRIN2]]|0.45|
|[[:human genes:t:tyms|TYMS]]|0.449|
|[[:human genes:r:rbm39|RBM39]]|0.449|
|[[:human genes:i:ik|IK]]|0.449|
|[[:human genes:l:lrr1|LRR1]]|0.448|
|[[:human genes:n:nufip2|NUFIP2]]|0.446|
|[[:human genes:a:asf1b|ASF1B]]|0.445|
|[[:human genes:r:rpl14|RPL14]]|0.445|
|[[:human genes:m:med14|MED14]]|0.445|
|[[:human genes:r:rrm1|RRM1]]|0.445|
|[[:human genes:n:naaladl1|NAALADL1]]|0.44|
|[[:human genes:p:pola2|POLA2]]|0.439|
|[[:human genes:k:krt78|KRT78]]|0.439|
|[[:human genes:c:col2a1|COL2A1]]|0.439|
|[[:human genes:k:kpnb1|KPNB1]]|0.438|
|[[:human genes:p:psmd11|PSMD11]]|0.438|
|[[:human genes:s:slc4a1|SLC4A1]]|0.438|
|[[:human genes:e:exosc6|EXOSC6]]|0.438|
|[[:human genes:u:upf1|UPF1]]|0.438|
|[[:human genes:p:psmc2|PSMC2]]|0.438|
|[[:human genes:p:psmc5|PSMC5]]|0.437|
|[[:human genes:m:myo1h|MYO1H]]|0.436|
|[[:human genes:d:dido1|DIDO1]]|0.436|
|[[:human genes:o:orc6|ORC6]]|0.436|
|[[:human genes:p:psmc4|PSMC4]]|0.436|
|[[:human genes:z:znf655|ZNF655]]|0.436|
|[[:human genes:z:znf541|ZNF541]]|0.435|
|[[:human genes:f:fcn2|FCN2]]|0.435|
|[[:human genes:p:polr2a|POLR2A]]|0.435|
|[[:human genes:c:cgb2|CGB2]]|0.435|
|[[:human genes:a:acsf2|ACSF2]]|0.435|
|[[:human genes:c:cdca5|CDCA5]]|0.434|
|[[:human genes:r:rrp15|RRP15]]|0.434|
|[[:human genes:n:nbpf10|NBPF10]]|0.434|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.433|
|[[:human genes:r:rfxank|RFXANK]]|0.433|
|[[:human genes:s:snip1|SNIP1]]|0.432|
|[[:human genes:s:sf3a1|SF3A1]]|0.432|
|[[:human genes:p:polr2d|POLR2D]]|0.431|
|[[:human genes:c:copa|COPA]]|0.431|
|[[:human genes:r:rrn3|RRN3]]|0.431|
|[[:human genes:a:aamp|AAMP]]|0.43|
|[[:human genes:m:myb|MYB]]|0.43|
|[[:human genes:p:ppfia4|PPFIA4]]|0.43|
|[[:human genes:d:dnm2|DNM2]]|0.43|
|[[:human genes:l:lad1|LAD1]]|0.43|
|[[:human genes:s:slc6a17|SLC6A17]]|0.429|
|[[:human genes:n:nup160|NUP160]]|0.429|
|[[:human genes:h:hivep3|HIVEP3]]|0.428|
|[[:human genes:p:psma7|PSMA7]]|0.427|
|[[:human genes:c:cope|COPE]]|0.426|
|[[:human genes:n:nup205|NUP205]]|0.426|
|[[:human genes:p:prkcz|PRKCZ]]|0.426|
|[[:human genes:a:atp6ap2|ATP6AP2]]|0.425|
|[[:human genes:c:copz1|COPZ1]]|0.425|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.425|
|[[:human genes:r:rps9|RPS9]]|0.425|
|[[:human genes:r:rpl35|RPL35]]|0.425|
|[[:human genes:p:pan2|PAN2]]|0.425|
|[[:human genes:z:znf830|ZNF830]]|0.425|
|[[:human genes:t:tfip11|TFIP11]]|0.424|
|[[:human genes:r:ranbp2|RANBP2]]|0.423|
|[[:human genes:n:ndc80|NDC80]]|0.422|
|[[:human genes:i:iscu|ISCU]]|0.421|
|[[:human genes:n:nup43|NUP43]]|0.42|
|[[:human genes:c:ctage9|CTAGE9]]|0.42|
|[[:human genes:n:nol10|NOL10]]|0.42|
|[[:human genes:r:rps14|RPS14]]|0.42|
|[[:human genes:n:nol12|NOL12]]|0.419|
|[[:human genes:r:rad51|RAD51]]|0.418|
|[[:human genes:n:nol8|NOL8]]|0.418|
|[[:human genes:c:copg1|COPG1]]|0.417|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.417|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.416|
|[[:human genes:g:golga8o|GOLGA8O]]|0.416|
|[[:human genes:r:rpl12|RPL12]]|0.414|
|[[:human genes:w:wdr87|WDR87]]|0.414|
|[[:human genes:p:pcf11|PCF11]]|0.414|
|[[:human genes:p:pole|POLE]]|0.414|
|[[:human genes:o:osbp|OSBP]]|0.413|
|[[:human genes:m:myt1l|MYT1L]]|0.413|
|[[:human genes:c:ctage4|CTAGE4]]|0.413|
|[[:human genes:c:cdc6|CDC6]]|0.412|
|[[:human genes:p:psma6|PSMA6]]|0.412|
|[[:human genes:i:igfn1|IGFN1]]|0.412|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.412|
|[[:human genes:p:plk4|PLK4]]|0.411|
|[[:human genes:s:sap30bp|SAP30BP]]|0.411|
|[[:human genes:d:ddx56|DDX56]]|0.411|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.41|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.41|
|[[:human genes:s:slc38a7|SLC38A7]]|0.409|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.409|
|[[:human genes:g:golga6a|GOLGA6A]]|0.408|
|[[:human genes:t:top1mt|TOP1MT]]|0.408|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.408|
|[[:human genes:r:rps5|RPS5]]|0.408|
|[[:human genes:s:sf3a3|SF3A3]]|0.408|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.408|
|[[:human genes:m:mdm2|MDM2]]|0.407|
|[[:human genes:p:psmb2|PSMB2]]|0.407|
|[[:human genes:c:cox8a|COX8A]]|0.405|
|[[:human genes:r:rrp7a|RRP7A]]|0.404|
|[[:human genes:p:psmb1|PSMB1]]|0.404|
|[[:human genes:s:ssrp1|SSRP1]]|0.404|
|[[:human genes:i:ints6|INTS6]]|0.404|
|[[:human genes:c:ciapin1|CIAPIN1]]|0.403|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.402|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.402|
|[[:human genes:c:cdc45|CDC45]]|0.402|
|[[:human genes:p:pwp2|PWP2]]|0.401|
|[[:human genes:c:ccdc94|CCDC94]]|0.401|
|[[:human genes:u:ubap1|UBAP1]]|0.4|
|[[:human genes:p:psmd8|PSMD8]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 526
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANKLE2 Expression in NALM6 Cells: 8.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>