ANO1 [The Human Chemical-Genetic Interaction Map Project]

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======= ANO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANO1
  * **<color #00a2e8>Official Name</color>**: anoctamin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55107|55107]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5XXA6|Q5XXA6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610108|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21984732, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:22946059}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Anoctamin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|iodide transmembrane transporter activity|
|iodide transport|
|voltage-gated chloride channel activity|
|calcium activated cation channel activity|
|detection of temperature stimulus involved in sensory perception|
|detection of temperature stimulus involved in sensory perception of pain|
|intracellular calcium activated chloride channel activity|
|detection of temperature stimulus|
|sensory perception of temperature stimulus|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|chloride channel complex|
|chloride channel activity|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|cellular response to heat|
|positive regulation of insulin secretion|
|sensory perception of pain|
|chloride transmembrane transport|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|positive regulation of peptide hormone secretion|
|chloride transport|
|inorganic anion transmembrane transport|
|response to heat|
|detection of external stimulus|
|detection of abiotic stimulus|
|positive regulation of hormone secretion|
|inorganic anion transport|
|response to temperature stimulus|
|regulation of insulin secretion|
|regulation of peptide hormone secretion|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|anion transmembrane transport|
|positive regulation of peptide secretion|
|apical plasma membrane|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of hormone levels|
|detection of stimulus involved in sensory perception|
|anion transport|
|inorganic ion transmembrane transport|
|detection of stimulus|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|cation transport|
|protein homodimerization activity|
|regulation of cellular localization|
|ion transmembrane transport|
|sensory perception|
|positive regulation of transport|
|regulation of protein localization|
|response to abiotic stimulus|
|transmembrane transport|
|G protein-coupled receptor signaling pathway|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|cellular response to stress|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.96|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12211
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANO1 Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>