ANO6 [The Human Chemical-Genetic Interaction Map Project]

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======= ANO6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANO6
  * **<color #00a2e8>Official Name</color>**: anoctamin 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=196527|196527]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q4KMQ2|Q4KMQ2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANO6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANO6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608663|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. {ECO:0000250|UniProtKB:Q6P9J9, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21107324, ECO:0000269|PubMed:21908539, ECO:0000269|PubMed:22006324, ECO:0000269|PubMed:22946059}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Anoctamin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylserine exposure on blood platelet|
|activation of blood coagulation via clotting cascade|
|positive regulation of potassium ion export across plasma membrane|
|calcium activated phosphatidylserine scrambling|
|calcium activated phospholipid scrambling|
|calcium activated galactosylceramide scrambling|
|negative regulation of cell volume|
|calcium activated phosphatidylcholine scrambling|
|bone mineralization involved in bone maturation|
|regulation of potassium ion export across plasma membrane|
|bleb assembly|
|phospholipid scramblase activity|
|voltage-gated chloride channel activity|
|positive regulation of phagocytosis, engulfment|
|positive regulation of membrane invagination|
|calcium activated cation channel activity|
|ossification involved in bone maturation|
|regulation of phagocytosis, engulfment|
|regulation of membrane invagination|
|bone maturation|
|intracellular calcium activated chloride channel activity|
|positive regulation of monocyte chemotaxis|
|plasma membrane phospholipid scrambling|
|dendritic cell chemotaxis|
|positive regulation of endothelial cell apoptotic process|
|pore complex assembly|
|dendritic cell migration|
|purinergic nucleotide receptor signaling pathway|
|animal organ maturation|
|positive regulation of mononuclear cell migration|
|regulation of monocyte chemotaxis|
|positive regulation of hemostasis|
|positive regulation of blood coagulation|
|cell volume homeostasis|
|positive regulation of coagulation|
|purinergic receptor signaling pathway|
|positive regulation of epithelial cell apoptotic process|
|positive regulation of potassium ion transmembrane transport|
|positive regulation of bone mineralization|
|phospholipid translocation|
|lipid translocation|
|voltage-gated ion channel activity|
|positive regulation of potassium ion transport|
|regulation of mononuclear cell migration|
|positive regulation of biomineral tissue development|
|positive regulation of biomineralization|
|bone mineralization|
|chloride channel complex|
|regulation of endothelial cell apoptotic process|
|regulation of membrane lipid distribution|
|positive regulation of wound healing|
|positive regulation of response to wounding|
|positive regulation of phagocytosis|
|acute inflammatory response|
|tertiary granule membrane|
|regulation of bone mineralization|
|regulation of blood coagulation|
|regulation of epithelial cell apoptotic process|
|regulation of potassium ion transmembrane transport|
|regulation of hemostasis|
|regulation of coagulation|
|positive regulation of ossification|
|positive regulation of leukocyte chemotaxis|
|chloride transmembrane transport|
|sodium ion transmembrane transport|
|specific granule membrane|
|phospholipid transport|
|biomineral tissue development|
|regulation of biomineral tissue development|
|biomineralization|
|plasma membrane organization|
|regulation of biomineralization|
|regulation of potassium ion transport|
|regulation of phagocytosis|
|positive regulation of endocytosis|
|chloride transport|
|inorganic anion transmembrane transport|
|regulation of leukocyte chemotaxis|
|organophosphate ester transport|
|positive regulation of leukocyte migration|
|anatomical structure maturation|
|positive regulation of chemotaxis|
|regulation of wound healing|
|positive regulation of cation transmembrane transport|
|leukocyte chemotaxis|
|sodium ion transport|
|positive regulation of ion transmembrane transport|
|inorganic anion transport|
|regulation of response to wounding|
|regulation of cell size|
|regulation of ossification|
|regulation of leukocyte migration|
|calcium ion transmembrane transport|
|bone development|
|positive regulation of transmembrane transport|
|regulation of endocytosis|
|cell chemotaxis|
|regulation of chemotaxis|
|developmental maturation|
|calcium ion transport|
|ossification|
|positive regulation of ion transport|
|anion transmembrane transport|
|blood coagulation|
|coagulation|
|divalent metal ion transport|
|hemostasis|
|lipid transport|
|divalent inorganic cation transport|
|lipid localization|
|regulation of cation transmembrane transport|
|regulation of cellular component size|
|leukocyte migration|
|regulation of metal ion transport|
|monovalent inorganic cation transport|
|endomembrane system organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|organic anion transport|
|regulation of ion transmembrane transport|
|wound healing|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|skeletal system development|
|regulation of body fluid levels|
|inflammatory response|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of anatomical structure size|
|myeloid leukocyte mediated immunity|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|positive regulation of cellular component movement|
|chemotaxis|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|taxis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|response to wounding|
|anion transport|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|cation transmembrane transport|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|metal ion transport|
|positive regulation of apoptotic process|
|inorganic ion transmembrane transport|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of ion transport|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|cation transport|
|regulation of cell migration|
|membrane organization|
|protein homodimerization activity|
|cellular homeostasis|
|regulation of cell motility|
|leukocyte activation|
|ion transmembrane transport|
|cell migration|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|secretion by cell|
|export from cell|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|secretion|
|positive regulation of immune system process|
|cell projection organization|
|positive regulation of cellular component organization|
|transmembrane transport|
|locomotion|
|defense response|
|positive regulation of developmental process|
|ion transport|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of programmed cell death|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|tissue development|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.91|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14728
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANO6 Expression in NALM6 Cells: 6.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>