ANP32B [The Human Chemical-Genetic Interaction Map Project]

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======= ANP32B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANP32B
  * **<color #00a2e8>Official Name</color>**: acidic nuclear phosphoprotein 32 family member B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10541|10541]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92688|Q92688]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANP32B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANP32B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619823|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome. {ECO:0000250, ECO:0000269|PubMed:20538007}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase binding|
|positive regulation of protein export from nucleus|
|ventricular system development|
|regulation of protein export from nucleus|
|positive regulation of nucleocytoplasmic transport|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|roof of mouth development|
|regulation of nucleocytoplasmic transport|
|nucleosome assembly|
|histone binding|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|chromatin assembly|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of intracellular protein transport|
|chromatin assembly or disassembly|
|nucleosome organization|
|positive regulation of endopeptidase activity|
|DNA packaging|
|positive regulation of peptidase activity|
|inner ear development|
|protein-DNA complex assembly|
|positive regulation of intracellular transport|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|ear development|
|regulation of intracellular protein transport|
|regulation of cysteine-type endopeptidase activity|
|protein-DNA complex subunit organization|
|DNA conformation change|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|positive regulation of proteolysis|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|regulation of peptidase activity|
|positive regulation of establishment of protein localization|
|vasculature development|
|cardiovascular system development|
|regulation of cellular protein localization|
|sensory organ development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|chromatin organization|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|positive regulation of hydrolase activity|
|head development|
|cellular protein-containing complex assembly|
|nucleolus|
|circulatory system development|
|regulation of cellular localization|
|negative regulation of developmental process|
|central nervous system development|
|positive regulation of transport|
|regulation of protein localization|
|chromosome organization|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.21|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.86|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.82|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.77|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.77|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.7|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:anp32a|ANP32A]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12177
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANP32B Expression in NALM6 Cells: 8.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>