ANXA6 [The Human Chemical-Genetic Interaction Map Project]

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======= ANXA6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANXA6
  * **<color #00a2e8>Official Name</color>**: annexin A6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=309|309]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08133|P08133]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANXA6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANXA6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114070|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Annexin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chondroitin sulfate binding|
|plasma membrane repair|
|ligand-gated ion channel activity|
|growth plate cartilage chondrocyte differentiation|
|mitochondrial calcium ion homeostasis|
|chondrocyte differentiation involved in endochondral bone morphogenesis|
|growth plate cartilage development|
|endochondral bone growth|
|bone growth|
|cartilage development involved in endochondral bone morphogenesis|
|cholesterol binding|
|calcium channel activity|
|neural crest cell migration|
|calcium-dependent phospholipid binding|
|negative regulation of sequestering of calcium ion|
|phosphatidylserine binding|
|calcium-dependent protein binding|
|endochondral bone morphogenesis|
|neural crest cell development|
|chondrocyte differentiation|
|mesenchymal cell development|
|stem cell development|
|neural crest cell differentiation|
|plasma membrane organization|
|organ growth|
|melanosome|
|bone morphogenesis|
|late endosome membrane|
|regulation of sequestering of calcium ion|
|lipid binding|
|mesenchymal cell differentiation|
|stem cell differentiation|
|regulation of muscle contraction|
|ameboidal-type cell migration|
|cartilage development|
|calcium ion transmembrane transport|
|bone development|
|actin filament binding|
|mesenchyme development|
|connective tissue development|
|regulation of muscle system process|
|skeletal system morphogenesis|
|calcium ion transport|
|apoptotic signaling pathway|
|divalent metal ion transport|
|lysosomal membrane|
|divalent inorganic cation transport|
|protein homooligomerization|
|collagen-containing extracellular matrix|
|developmental growth|
|GTP binding|
|growth|
|focal adhesion|
|endomembrane system organization|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|wound healing|
|divalent inorganic cation homeostasis|
|skeletal system development|
|protein complex oligomerization|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|response to wounding|
|regulation of system process|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|perinuclear region of cytoplasm|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|membrane organization|
|protein homodimerization activity|
|cellular homeostasis|
|apoptotic process|
|ion transmembrane transport|
|animal organ morphogenesis|
|cell migration|
|programmed cell death|
|cell motility|
|localization of cell|
|cell death|
|chemical homeostasis|
|mitochondrion|
|transmembrane transport|
|locomotion|
|ion transport|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|homeostatic process|
|cell development|
|tissue development|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp134|MS023 2μM R03 exp134]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3795
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANXA6 Expression in NALM6 Cells: 5.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>