AP2B1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= AP2B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AP2B1
  * **<color #00a2e8>Official Name</color>**: adaptor related protein complex 2 subunit beta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=163|163]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P63010|P63010]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AP2B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AP2B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601025|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin- associated sorting proteins (CLASPs) are recognized by their [DE]- X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly. {ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cnd1|
|Alpha adaptinC2|
|Adaptin N|
|B2-adapt-app C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|signal sequence binding|
|postsynaptic endocytosis|
|postsynaptic neurotransmitter receptor internalization|
|low-density lipoprotein particle receptor catabolic process|
|clathrin adaptor activity|
|low-density lipoprotein receptor particle metabolic process|
|neurotransmitter receptor internalization|
|endolysosome membrane|
|AP-2 adaptor complex|
|clathrin coat assembly|
|low-density lipoprotein particle clearance|
|clathrin-coated endocytic vesicle|
|clathrin-dependent endocytosis|
|receptor catabolic process|
|regulation of defense response to virus by virus|
|clathrin-coated endocytic vesicle membrane|
|neurotransmitter receptor transport|
|clathrin binding|
|plasma lipoprotein particle clearance|
|coronary vasculature development|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|aorta development|
|receptor internalization|
|endocytic vesicle membrane|
|regulation of plasma lipoprotein particle levels|
|ventricular septum development|
|postsynapse|
|artery development|
|ephrin receptor signaling pathway|
|Wnt signaling pathway, planar cell polarity pathway|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|positive regulation of endocytosis|
|receptor metabolic process|
|cardiac septum development|
|regulation of establishment of planar polarity|
|positive regulation of protein localization to membrane|
|cardiac ventricle development|
|vesicle-mediated transport in synapse|
|non-canonical Wnt signaling pathway|
|cardiac chamber development|
|antigen processing and presentation of exogenous peptide antigen|
|regulation of morphogenesis of an epithelium|
|antigen processing and presentation of exogenous antigen|
|regulation of protein localization to membrane|
|antigen processing and presentation of peptide antigen|
|regulation of endocytosis|
|negative regulation of neuron death|
|antigen processing and presentation|
|receptor-mediated endocytosis|
|protein-containing complex localization|
|regulation of animal organ morphogenesis|
|protein-containing complex binding|
|regulation of neuron death|
|positive regulation of cellular protein localization|
|glutamatergic synapse|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|establishment of protein localization to organelle|
|blood vessel development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|cardiovascular system development|
|heart development|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|endocytosis|
|cellular protein catabolic process|
|import into cell|
|protein catabolic process|
|viral process|
|enzyme linked receptor protein signaling pathway|
|protein localization to organelle|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|membrane organization|
|circulatory system development|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|positive regulation of transport|
|intracellular protein transport|
|negative regulation of cell death|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|positive regulation of cellular component organization|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell death|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15008
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AP2B1 Expression in NALM6 Cells: 7.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>