AP3B1 [The Human Chemical-Genetic Interaction Map Project]

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======= AP3B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AP3B1
  * **<color #00a2e8>Official Name</color>**: adaptor related protein complex 3 subunit beta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8546|8546]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00203|O00203]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AP3B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AP3B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603401|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Adaptin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|synaptic vesicle budding from endosome|
|synaptic vesicle recycling via endosome|
|positive regulation of NK T cell differentiation|
|regulation of NK T cell differentiation|
|antigen processing and presentation of lipid antigen via MHC class Ib|
|antigen processing and presentation, exogenous lipid antigen via MHC class Ib|
|synaptic vesicle endosomal processing|
|synaptic vesicle budding|
|clathrin adaptor complex|
|AP-3 adaptor complex|
|synaptic vesicle transport along microtubule|
|synaptic vesicle cytoskeletal transport|
|anterograde synaptic vesicle transport|
|antigen processing and presentation via MHC class Ib|
|protein targeting to lysosome|
|GTP-dependent protein binding|
|melanosome organization|
|pigment granule organization|
|synaptic vesicle transport|
|protein targeting to vacuole|
|protein localization to lysosome|
|synaptic vesicle localization|
|vesicle transport along microtubule|
|anterograde axonal transport|
|positive regulation of alpha-beta T cell differentiation|
|establishment of protein localization to vacuole|
|cellular pigmentation|
|vesicle cytoskeletal trafficking|
|synaptic vesicle recycling|
|clathrin-coated vesicle membrane|
|axonal transport|
|axon cytoplasm|
|positive regulation of alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|protein localization to vacuole|
|axo-dendritic transport|
|organelle transport along microtubule|
|positive regulation of T cell differentiation|
|protein phosphatase binding|
|pigmentation|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|vesicle budding from membrane|
|lysosomal transport|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|regulation of T cell differentiation|
|vacuolar transport|
|positive regulation of leukocyte differentiation|
|transport along microtubule|
|regulation of lymphocyte differentiation|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|antigen processing and presentation of exogenous antigen|
|vesicle localization|
|positive regulation of hemopoiesis|
|positive regulation of T cell activation|
|positive regulation of leukocyte cell-cell adhesion|
|antigen processing and presentation|
|endosomal transport|
|positive regulation of cell-cell adhesion|
|synapse|
|microtubule-based movement|
|regulation of leukocyte differentiation|
|blood coagulation|
|coagulation|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|vesicle organization|
|lysosomal membrane|
|regulation of T cell activation|
|protein targeting|
|positive regulation of lymphocyte activation|
|establishment of organelle localization|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|establishment of protein localization to organelle|
|regulation of hemopoiesis|
|wound healing|
|regulation of body fluid levels|
|regulation of lymphocyte activation|
|response to wounding|
|organelle localization|
|regulation of leukocyte activation|
|regulation of cell activation|
|microtubule-based process|
|regulation of cell adhesion|
|protein localization to organelle|
|membrane organization|
|positive regulation of cell differentiation|
|Golgi apparatus|
|intracellular protein transport|
|positive regulation of immune system process|
|positive regulation of developmental process|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.05|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.03|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.02|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.93|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.92|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.84|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.7|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14312
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AP3B1 Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>