API5 [The Human Chemical-Genetic Interaction Map Project]

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======= API5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: API5
  * **<color #00a2e8>Official Name</color>**: apoptosis inhibitor 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8539|8539]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BZZ5|Q9BZZ5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=API5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20API5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609774|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. {ECO:0000269|PubMed:10780674, ECO:0000269|PubMed:17112319, ECO:0000269|PubMed:19387494}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|API5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of fibroblast apoptotic process|
|regulation of fibroblast apoptotic process|
|fibroblast growth factor binding|
|spliceosomal complex|
|nuclear speck|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|negative regulation of cell death|
|programmed cell death|
|cell death|
|RNA binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.75|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.17|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.1|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.09|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.78|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.77|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.77|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.81|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.44|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13870
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='API5 Expression in NALM6 Cells: 7.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>