APITD1 [The Human Chemical-Genetic Interaction Map Project]

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======= APITD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CENPS
  * **<color #00a2e8>Official Name</color>**: centromere protein S
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=378708|378708]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N2Z9|Q8N2Z9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APITD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APITD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609130|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM (PubMed:20347428, PubMed:20347429). In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428). In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:22304917). DNA- binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347428, PubMed:20347429). {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:22304917}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|FANCM-MHF complex|
|kinetochore assembly|
|Fanconi anaemia nuclear complex|
|resolution of meiotic recombination intermediates|
|kinetochore organization|
|meiotic chromosome separation|
|CENP-A containing nucleosome assembly|
|chromosome separation|
|replication fork processing|
|CENP-A containing chromatin organization|
|chromatin remodeling at centromere|
|centromere complex assembly|
|DNA replication-independent nucleosome assembly|
|DNA-dependent DNA replication maintenance of fidelity|
|DNA replication-independent nucleosome organization|
|histone exchange|
|reciprocal meiotic recombination|
|homologous recombination|
|interstrand cross-link repair|
|ATP-dependent chromatin remodeling|
|condensed chromosome kinetochore|
|meiotic chromosome segregation|
|double-stranded DNA binding|
|meiosis I|
|meiosis I cell cycle process|
|positive regulation of protein ubiquitination|
|nucleosome assembly|
|DNA-dependent DNA replication|
|positive regulation of protein modification by small protein conjugation or removal|
|chromatin assembly|
|meiotic nuclear division|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|meiotic cell cycle process|
|DNA packaging|
|regulation of protein ubiquitination|
|protein-DNA complex assembly|
|DNA replication|
|nuclear chromosome segregation|
|DNA recombination|
|meiotic cell cycle|
|regulation of protein modification by small protein conjugation or removal|
|protein-DNA complex subunit organization|
|chromosome segregation|
|nuclear division|
|DNA conformation change|
|organelle fission|
|chromatin binding|
|protein heterodimerization activity|
|cell division|
|DNA repair|
|chromatin organization|
|DNA metabolic process|
|organelle assembly|
|cellular response to DNA damage stimulus|
|cellular protein-containing complex assembly|
|cell cycle process|
|chromosome organization|
|positive regulation of protein modification process|
|cell cycle|
|reproductive process|
|reproduction|
|DNA binding|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-3.7|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-3.39|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.31|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.01|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.77|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|4.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:stra13|STRA13]]|0.583|
|[[:human genes:f:fancm|FANCM]]|0.403|
|[[:human genes:s:swsap1|SWSAP1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6310
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APITD1 Expression in NALM6 Cells: 3.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>