APLNR [The Human Chemical-Genetic Interaction Map Project]

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======= APLNR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APLNR
  * **<color #00a2e8>Official Name</color>**: apelin receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=187|187]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35414|P35414]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APLNR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APLNR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600052|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)- derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:25639753, PubMed:28137936). {ECO:0000250|UniProtKB:P79960, ECO:0000250|UniProtKB:Q7SZP9, ECO:0000250|UniProtKB:Q9WV08, ECO:0000269|PubMed:11090199, ECO:0000269|PubMed:25639753, ECO:0000269|PubMed:28137936}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of inhibitory G protein-coupled receptor phosphorylation|
|apelin receptor activity|
|regulation of inhibitory G protein-coupled receptor phosphorylation|
|apelin receptor signaling pathway|
|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|adult heart development|
|negative regulation of cAMP-mediated signaling|
|positive regulation of sprouting angiogenesis|
|positive regulation of release of sequestered calcium ion into cytosol|
|coronary vasculature development|
|regulation of cAMP-mediated signaling|
|positive regulation of calcium ion transport into cytosol|
|vasculogenesis|
|regulation of sprouting angiogenesis|
|positive regulation of calcium ion transmembrane transport|
|regulation of release of sequestered calcium ion into cytosol|
|positive regulation of endothelial cell proliferation|
|regulation of calcium ion transport into cytosol|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|regulation of endothelial cell proliferation|
|positive regulation of cation transmembrane transport|
|regulation of G protein-coupled receptor signaling pathway|
|regulation of calcium ion transmembrane transport|
|positive regulation of ion transmembrane transport|
|gastrulation|
|positive regulation of angiogenesis|
|positive regulation of vasculature development|
|positive regulation of epithelial cell proliferation|
|positive regulation of transmembrane transport|
|signaling receptor activity|
|regulation of calcium ion transport|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|regulation of angiogenesis|
|angiogenesis|
|regulation of vasculature development|
|regulation of cytosolic calcium ion concentration|
|regulation of epithelial cell proliferation|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|blood vessel morphogenesis|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|blood vessel development|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|negative regulation of intracellular signal transduction|
|vasculature development|
|cardiovascular system development|
|heart development|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|embryonic morphogenesis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|tube morphogenesis|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|ion homeostasis|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|embryo development|
|positive regulation of transport|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10578
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APLNR Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>