APOA2 [The Human Chemical-Genetic Interaction Map Project]

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======= APOA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APOA2
  * **<color #00a2e8>Official Name</color>**: apolipoprotein A2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=336|336]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02652|P02652]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APOA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APOA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107670|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ApoA-II|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cholesterol transporter activity|
|negative regulation of lipid transporter activity|
|negative regulation of cholesterol import|
|regulation of cholesterol transporter activity|
|negative regulation of sterol import|
|negative regulation of very-low-density lipoprotein particle remodeling|
|apolipoprotein receptor binding|
|high-density lipoprotein particle receptor binding|
|regulation of lipid transporter activity|
|diacylglycerol catabolic process|
|regulation of sterol import|
|regulation of cholesterol import|
|regulation of very-low-density lipoprotein particle remodeling|
|negative regulation of cytokine secretion involved in immune response|
|phosphatidylcholine-sterol O-acyltransferase activator activity|
|lipase inhibitor activity|
|regulation of intestinal cholesterol absorption|
|regulation of intestinal lipid absorption|
|spherical high-density lipoprotein particle|
|positive regulation of cholesterol esterification|
|regulation of intestinal absorption|
|chylomicron remodeling|
|high-density lipoprotein particle clearance|
|high-density lipoprotein particle binding|
|chylomicron assembly|
|regulation of cholesterol esterification|
|negative regulation of cholesterol transport|
|phospholipid efflux|
|positive regulation of interleukin-8 biosynthetic process|
|negative regulation of sterol transport|
|high-density lipoprotein particle assembly|
|protein oxidation|
|chylomicron|
|low-density lipoprotein particle remodeling|
|peptidyl-methionine modification|
|triglyceride-rich lipoprotein particle remodeling|
|regulation of interleukin-8 biosynthetic process|
|reverse cholesterol transport|
|regulation of cytokine secretion involved in immune response|
|negative regulation of lipase activity|
|cholesterol transfer activity|
|high-density lipoprotein particle remodeling|
|very-low-density lipoprotein particle|
|diacylglycerol metabolic process|
|high-density lipoprotein particle|
|negative regulation of lipid catabolic process|
|cholesterol efflux|
|positive regulation of lipid catabolic process|
|negative regulation of cytokine production involved in immune response|
|negative regulation of lipid transport|
|plasma lipoprotein particle assembly|
|positive regulation of steroid metabolic process|
|phosphatidylcholine binding|
|plasma lipoprotein particle remodeling|
|protein-lipid complex remodeling|
|protein-containing complex remodeling|
|lipid transporter activity|
|protein-lipid complex assembly|
|phosphatidylcholine biosynthetic process|
|negative regulation of production of molecular mediator of immune response|
|neutral lipid catabolic process|
|acylglycerol catabolic process|
|phospholipid catabolic process|
|regulation of digestive system process|
|plasma lipoprotein particle clearance|
|negative regulation of lipid localization|
|plasma lipoprotein particle organization|
|regulation of cholesterol transport|
|regulation of sterol transport|
|protein-lipid complex subunit organization|
|positive regulation of interleukin-8 production|
|cholesterol binding|
|glycerolipid catabolic process|
|cholesterol transport|
|regulation of lipid catabolic process|
|heat shock protein binding|
|sterol transport|
|positive regulation of cytokine biosynthetic process|
|negative regulation of cytokine secretion|
|positive regulation of phagocytosis|
|regulation of interleukin-8 production|
|acute inflammatory response|
|regulation of plasma lipoprotein particle levels|
|animal organ regeneration|
|triglyceride metabolic process|
|response to estrogen|
|phosphatidylcholine metabolic process|
|negative regulation of transporter activity|
|cholesterol homeostasis|
|sterol homeostasis|
|negative regulation of lipid metabolic process|
|regulation of cytokine production involved in immune response|
|phospholipid transport|
|regulation of phagocytosis|
|regulation of lipase activity|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|retinoid metabolic process|
|phospholipid binding|
|regulation of cytokine biosynthetic process|
|regulation of lipid transport|
|diterpenoid metabolic process|
|regulation of steroid metabolic process|
|cholesterol metabolic process|
|lipoprotein metabolic process|
|terpenoid metabolic process|
|negative regulation of immune effector process|
|organophosphate ester transport|
|organophosphate catabolic process|
|secondary alcohol metabolic process|
|negative regulation of protein secretion|
|lipid homeostasis|
|sterol metabolic process|
|isoprenoid metabolic process|
|organic hydroxy compound transport|
|response to glucose|
|regulation of lipid localization|
|negative regulation of peptide secretion|
|regulation of production of molecular mediator of immune response|
|blood microparticle|
|positive regulation of lipid metabolic process|
|response to hexose|
|response to glucocorticoid|
|negative regulation of immune response|
|response to monosaccharide|
|lipid binding|
|regeneration|
|response to corticosteroid|
|response to carbohydrate|
|protein stabilization|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|negative regulation of secretion|
|phospholipid biosynthetic process|
|early endosome|
|steroid metabolic process|
|negative regulation of cytokine production|
|regulation of transporter activity|
|regulation of protein stability|
|lipid transport|
|lipid catabolic process|
|endoplasmic reticulum lumen|
|glycerophospholipid metabolic process|
|negative regulation of catabolic process|
|alcohol metabolic process|
|lipid localization|
|response to steroid hormone|
|signaling receptor binding|
|post-translational protein modification|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|extracellular structure organization|
|regulation of lipid metabolic process|
|positive regulation of catabolic process|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|negative regulation of hydrolase activity|
|organic hydroxy compound metabolic process|
|organic anion transport|
|regulation of protein secretion|
|regulation of immune effector process|
|negative regulation of transport|
|protein heterodimerization activity|
|regulation of peptide secretion|
|inflammatory response|
|organophosphate biosynthetic process|
|regulation of vesicle-mediated transport|
|lipid biosynthetic process|
|anion transport|
|regulation of system process|
|regulation of cytokine production|
|viral process|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|symbiotic process|
|negative regulation of catalytic activity|
|regulation of secretion|
|interspecies interaction between organisms|
|response to lipid|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|organophosphate metabolic process|
|response to hormone|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|oxidation-reduction process|
|positive regulation of transport|
|regulation of catabolic process|
|response to drug|
|regulation of protein localization|
|chemical homeostasis|
|negative regulation of molecular function|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|regulation of hydrolase activity|
|defense response|
|ion transport|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17285
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APOA2 Expression in NALM6 Cells: -1.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>