APOC1 [The Human Chemical-Genetic Interaction Map Project]

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======= APOC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APOC1
  * **<color #00a2e8>Official Name</color>**: apolipoprotein C1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=341|341]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02654|P02654]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APOC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APOC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107710|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein. {ECO:0000269|PubMed:17339654, ECO:0000303|PubMed:25160599}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ApoC-I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of phosphatidylcholine catabolic process|
|regulation of phosphatidylcholine catabolic process|
|regulation of very-low-density lipoprotein particle clearance|
|negative regulation of very-low-density lipoprotein particle clearance|
|very-low-density lipoprotein particle clearance|
|regulation of phospholipid catabolic process|
|phosphatidylcholine-sterol O-acyltransferase activator activity|
|lipase inhibitor activity|
|negative regulation of lipoprotein lipase activity|
|phospholipase inhibitor activity|
|chylomicron remnant clearance|
|negative regulation of lipoprotein particle clearance|
|triglyceride-rich lipoprotein particle clearance|
|positive regulation of cholesterol esterification|
|negative regulation of phospholipid metabolic process|
|regulation of cholesterol esterification|
|very-low-density lipoprotein particle assembly|
|negative regulation of cholesterol transport|
|phospholipid efflux|
|negative regulation of sterol transport|
|chylomicron|
|negative regulation of fatty acid biosynthetic process|
|negative regulation of lipase activity|
|regulation of lipoprotein particle clearance|
|high-density lipoprotein particle remodeling|
|very-low-density lipoprotein particle|
|regulation of lipoprotein lipase activity|
|high-density lipoprotein particle|
|negative regulation of lipid catabolic process|
|cholesterol efflux|
|fatty acid binding|
|negative regulation of receptor-mediated endocytosis|
|negative regulation of fatty acid metabolic process|
|negative regulation of lipid transport|
|plasma lipoprotein particle assembly|
|positive regulation of steroid metabolic process|
|phosphatidylcholine binding|
|plasma lipoprotein particle remodeling|
|protein-lipid complex remodeling|
|protein-containing complex remodeling|
|protein-lipid complex assembly|
|plasma lipoprotein particle clearance|
|negative regulation of lipid localization|
|negative regulation of endocytosis|
|plasma lipoprotein particle organization|
|regulation of fatty acid biosynthetic process|
|regulation of cholesterol transport|
|regulation of sterol transport|
|protein-lipid complex subunit organization|
|negative regulation of lipid biosynthetic process|
|cholesterol transport|
|regulation of lipid catabolic process|
|sterol transport|
|regulation of plasma lipoprotein particle levels|
|triglyceride metabolic process|
|negative regulation of lipid metabolic process|
|regulation of phospholipid metabolic process|
|regulation of fatty acid metabolic process|
|negative regulation of small molecule metabolic process|
|phospholipid transport|
|regulation of lipase activity|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|regulation of receptor-mediated endocytosis|
|regulation of lipid transport|
|regulation of steroid metabolic process|
|cholesterol metabolic process|
|lipoprotein metabolic process|
|organophosphate ester transport|
|secondary alcohol metabolic process|
|sterol metabolic process|
|organic hydroxy compound transport|
|regulation of lipid localization|
|positive regulation of lipid metabolic process|
|regulation of cellular ketone metabolic process|
|regulation of lipid biosynthetic process|
|regulation of endocytosis|
|negative regulation of cellular catabolic process|
|steroid metabolic process|
|lipid transport|
|negative regulation of catabolic process|
|alcohol metabolic process|
|lipid localization|
|glycerolipid metabolic process|
|extracellular structure organization|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|negative regulation of hydrolase activity|
|organic hydroxy compound metabolic process|
|organic anion transport|
|negative regulation of transport|
|regulation of vesicle-mediated transport|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|anion transport|
|negative regulation of cellular component organization|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|cellular lipid metabolic process|
|regulation of catabolic process|
|endoplasmic reticulum|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|regulation of hydrolase activity|
|ion transport|
|positive regulation of catalytic activity|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|protein-containing complex subunit organization|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7737
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APOC1 Expression in NALM6 Cells: -2.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>